Key criteria for the ethical acceptability of COVID-19 human challenge studies: Report of a WHO Working Group
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DOI: 10.1016/j.vaccine.2020.10.075
Abstract: This report of WHO Working Group for Guidance on Human Challenge Studies in COVID-19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria related to scientific justification, risk-benefit assessment, consultation and engagement,… read more here.
Keywords: working group; challenge; challenge studies; human challenge ... See more keywords
Human challenge models: tools to accelerate the development of malaria vaccines
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DOI: 10.1080/14760584.2019.1580577
Abstract: ABSTRACT Introduction: Malaria challenge models, where healthy human volunteers are intentionally infected with Plasmodium species parasites under controlled conditions, can be undertaken in several well-defined ways. These challenge models enable evaluation of the kinetics of… read more here.
Keywords: challenge models; malaria vaccines; human challenge; development ... See more keywords
Controlled Human Infection Models To Accelerate Vaccine Development
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DOI: 10.1128/cmr.00008-21
Abstract: The timelines for developing vaccines against infectious diseases are lengthy, and often vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of protective efficacy. The application of… read more here.
Keywords: controlled human; development; infection; human challenge ... See more keywords
Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study
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DOI: 10.12688/wellcomeopenres.17516.1
Abstract: Background: Human challenge studies involve the deliberate exposure of healthy volunteers to an infectious micro-organism in a highly controlled and monitored way. They are used to understand infectious diseases and have contributed to the development… read more here.
Keywords: challenge study; study sars; human challenge; study ... See more keywords
A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses
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DOI: 10.1371/journal.pntd.0007823
Abstract: Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy is to target strains… read more here.
Keywords: based vaccine; challenge; human challenge; vaccine ... See more keywords
The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
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DOI: 10.3389/fcimb.2019.00107
Abstract: Objectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for… read more here.
Keywords: human challenge; influenza; vaccinology; biology ... See more keywords