Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00804-3
Abstract: Gene regulatory divergence is thought to play a central role in determining human-specific traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells… read more here.
Keywords: hedgehog signaling; regulatory divergence; human chimpanzee; chimpanzee fused ... See more keywords
Human and chimpanzee shared and divergent neurobiological systems for general and specific cognitive brain functions.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218565120
Abstract: A long-standing topic of interest in human neurosciences is the understanding of the neurobiology underlying human cognition. Less commonly considered is to what extent such systems may be shared with other species. We examined individual… read more here.
Keywords: connectivity; specific cognitive; cognition; human chimpanzee ... See more keywords
Differentially Active and Conserved Neural Enhancers Define Two Forms of Adaptive Noncoding Evolution in Humans
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac108
Abstract: Abstract The human and chimpanzee genomes are strikingly similar, but our neural phenotypes are very different. Many of these differences are likely driven by changes in gene expression, and some of those changes may have… read more here.
Keywords: human chimpanzee; differentially active; active conserved; evolution humans ... See more keywords
The Impact of Sample Size and Population History on Observed Mutational Spectra: A Case Study in Human and Chimpanzee Populations
Sign Up to like & getrecommendations! Published in 2023 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evad019
Abstract: Abstract Recent studies have highlighted variation in the mutational spectra among human populations as well as closely related hominoids—yet little remains known about the genetic and nongenetic factors driving these rate changes across the genome.… read more here.
Keywords: human chimpanzee; sample size; mutational spectra; chimpanzee populations ... See more keywords
Comparative Functional Morphology of Human and Chimpanzee Feet Based on Three-Dimensional Finite Element Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.760486
Abstract: To comparatively investigate the morphological adaptation of the human foot for achieving robust and efficient bipedal locomotion, we develop three-dimensional finite element models of the human and chimpanzee feet. Foot bones and the outer surface… read more here.
Keywords: human chimpanzee; finite element; dimensional finite; three dimensional ... See more keywords