Compound C induces protective autophagy in human cholangiocarcinoma cells via Akt/mTOR‐independent pathway
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DOI: 10.1002/jcb.26723
Abstract: Compound C, a well‐known inhibitor of AMP‐activated protein kinase (AMPK), has been reported to exert antitumor activities in some types of cells. Whether compound C can exert antitumor effects in human cholangiocarcinoma (CCA) remains unknown.… read more here.
Keywords: human cholangiocarcinoma; human cca; compound; mtor ... See more keywords
Induction of cell‐cycle arrest and apoptosis in human cholangiocarcinoma cells by pristimerin
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DOI: 10.1002/jcb.28485
Abstract: Pristimerin, a triterpenoid isolated from Celastraceae and Hippocrateaceae, is known to induce cytotoxicity in several cancer cell lines. However, whether pristimerin can induce apoptosis in cholangiocarcinoma cells and the underlying mechanism remain unexplored. We assessed… read more here.
Keywords: human cholangiocarcinoma; cell; cell cycle; apoptosis ... See more keywords
CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma
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DOI: 10.3389/fcell.2020.00417
Abstract: Background: Our previous study demonstrated an overexpression of CD44 variant 9 (CD44v9) in human cholangiocarcinoma (CCA) tissues that was associated with inflammation-related tumor development. However, the participation of CD44v9 in cholangiocarcinogenesis remains poorly understood. Therefore,… read more here.
Keywords: cca cells; human cholangiocarcinoma; cd44v9; expression levels ... See more keywords
Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01238
Abstract: Background: Human cholangiocarcinoma (CCA) is a highly lethal cancer that occurs in the biliary tract. It is characterized by early invasion, poor outcomes, and resistance to current chemotherapies. To date, an effective therapeutic strategy for… read more here.
Keywords: proliferation; cca; human cholangiocarcinoma; pterostilbene ... See more keywords