MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes
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DOI: 10.1002/jcb.26669
Abstract: Micro(mi)RNAs are small, non‐coding RNA molecules known to play a significant role in osteoarthritis (OA) initiation and development, and similar to matrix metalloproteinases (MMPs), they participate in cartilage degeneration and cleave multiple extracellular matrices. The… read more here.
Keywords: induced human; interleukin induced; human chondrocytes; mmp ... See more keywords
Teneligliptin inhibits IL‐1β‐induced degradation of extracellular matrix in human chondrocytes
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DOI: 10.1002/jcb.29662
Abstract: The mechanisms driving the pathologic progression of osteoarthritis (OA) have not yet to be fully elucidated. Excessive and irreversible breakdown of the extracellular matrix is the main hallmark of OA. Inhibitors of DPP‐4 have been… read more here.
Keywords: teneligliptin inhibits; extracellular matrix; human chondrocytes; inhibits induced ... See more keywords
Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-κB and p38/MAPK signaling pathway
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DOI: 10.1007/s00774-019-01016-w
Abstract: Several cellular and molecular processes participate in the pathologic changes of osteoarthritis (OA). However, the core molecular regulators of these processes are unclear, and no effective treatment for OA disease has been developed so far.… read more here.
Keywords: p38 mapk; upregulation promotes; mapk signaling; human chondrocytes ... See more keywords
Endocan, a novel inflammatory marker, is upregulated in human chondrocytes stimulated with IL-1 beta.
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DOI: 10.1007/s11010-020-04001-4
Abstract: Endocan is a circulating proteoglycan, involved in immunity, inflammation, and endothelial function. It has been recently suggested as a biomarker of inflammation, increased angiogenesis, and cancer. In vitro studies have shown that endocan expression could… read more here.
Keywords: endocan novel; human chondrocytes; chondrocytes stimulated; inflammatory ... See more keywords
Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b
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DOI: 10.1007/s11010-021-04186-2
Abstract: Osteoarthritis (OA) is a chronic disease characterized by articular cartilage degeneration and uncontrolled chondrocyte apoptosis. At present, accumulating evidence introduces that circular RNA (circRNA) is involved in the development of OA. The aim of our… read more here.
Keywords: apoptosis; mir 23b; human chondrocytes; spry1 ... See more keywords
miR9 inhibits 6-mer HA-induced cytokine production and apoptosis in human chondrocytes by reducing NF-kB activation.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109139
Abstract: The present study aimed to investigate the expression of miR9 and its correlation with cytokines, proteolytic enzymes and apoptosis in an experimental model of 6-mer HA induced inflammation in human chondrocytes. Human articular chondrocytes, transfected… read more here.
Keywords: mer; activation; mer induced; human chondrocytes ... See more keywords
Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monboxylate Transporter 4.
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DOI: 10.1016/j.bone.2021.116299
Abstract: Osteoarthritis (OA) is a common joint disease lacking effective treatments. Dexamethasone (Dex) is often used to relieve joint pain. However, the adverse effects of Dex on cartilage can't be ignored. This study aimed to investigate… read more here.
Keywords: lactic acid; chondrocytes via; level; human chondrocytes ... See more keywords
Imperatorin suppresses IL-1β-induced iNOS expression via inhibiting ERK-MAPK/AP1 signaling in primary human OA chondrocytes.
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DOI: 10.1016/j.intimp.2020.106612
Abstract: Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated… read more here.
Keywords: erk mapk; human chondrocytes; expression; mapk ap1 ... See more keywords
Primary human chondrocytes respond to compression with phosphoproteomic signatures that include microtubule activation.
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DOI: 10.1016/j.jbiomech.2019.109367
Abstract: Chondrocytes are responsible for maintaining the cartilage that helps joints bear load and move smoothly. These cells typically respond to physiological compression with pathways consistent with matrix synthesis, and chondrocyte mechanotransduction is essential for homeostasis.… read more here.
Keywords: compression phosphoproteomic; compression; chondrocytes respond; human chondrocytes ... See more keywords
In vitro augmentation of chondrogenesis by Epigallocatechin gallate in primary Human chondrocytes - Sustained release model for cartilage regeneration
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DOI: 10.1016/j.jddst.2020.101992
Abstract: Abstract Epigallocatechin-3-gallate (EGCG), a plant polyphenol catechin is potent chondrogenic drug which enhances cartilage regeneration. Hence, sustained release of EGCG from interlinked porous polycaprolactone (PCL) scaffolds can be beneficial in engineering a cartilage construct. In… read more here.
Keywords: human chondrocytes; epigallocatechin gallate; sustained release; cartilage regeneration ... See more keywords
CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.
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DOI: 10.1016/j.joca.2018.09.001
Abstract: OBJECTIVE To investigate the efficacy of CRISPR-Cas9 mediated editing in human chondrocytes, and to develop a genome editing approach relevant to cell-based repair. METHODS Transfection of human articular chondrocytes (both healthy and osteoarthritic) with ribonucleoprotein… read more here.
Keywords: crispr cas9; type collagen; human chondrocytes; cas9 ... See more keywords