Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells
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DOI: 10.1038/s41598-017-03958-5
Abstract: Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the maintenance of chondrocyte… read more here.
Keywords: phenotype; human chondrosarcoma; s100 protein; s100 s100 ... See more keywords
Abstract 6128: Deubiquitinating enzyme Inhibitor PR-619 inducesendoplasmic reticulum stress-related apoptosisin human chondrosarcoma
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DOI: 10.1158/1538-7445.am2023-6128
Abstract: It is reported that PR-619 is a deubiquitination enzyme inhibitor that can exert anti-tumor effects on a variety of malignancies. We conducted this study to explore the antitumor effects of PR-619 on chondrosarcoma in vitro… read more here.
Keywords: stress; human chondrosarcoma; chondrosarcoma; reticulum ... See more keywords
Cellular and Molecular Biological Alterations after Photon, Proton, and Carbon Ions Irradiation in Human Chondrosarcoma Cells Linked with High-Quality Physics Data
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DOI: 10.3390/ijms231911464
Abstract: Chondrosarcomas are particularly difficult to treat due to their resistance to chemotherapy and radiotherapy. However, particle therapy can enhance local control and patient survival rates. To improve our understanding of the basic cellular radiation response,… read more here.
Keywords: cell; physics; proton carbon; human chondrosarcoma ... See more keywords
The ATR Inhibitor VE-821 Enhances the Radiosensitivity and Suppresses DNA Repair Mechanisms of Human Chondrosarcoma Cells
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DOI: 10.3390/ijms24032315
Abstract: To overcome the resistance to radiotherapy in chondrosarcomas, the prevention of efficient DNA repair with an additional treatment was explored for particle beams as well as reference X-ray irradiation. The combined treatment with DNA repair… read more here.
Keywords: dna repair; human chondrosarcoma; expression; treatment ... See more keywords