Efficient secretory expression of type III recombinant human collagen with triple-helical structure in Komagataella phaffii
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13566-3
Abstract: Recombinant human collagen (rhCol) holds broad potential in biomedical and industrial applications due to its high purity and low immunogenicity. However, large-scale production of structurally stable and functionally active rhCol remains challenging. A novel strategy… read more here.
Keywords: triple helical; collagen; recombinant human; expression ... See more keywords
Increase in the incidence of acute inflammatory reactions to injectable fillers during COVID-19 era.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.14886
Abstract: BACKGROUND Acute inflammatory reactions (AIRs) are a rare complication following aesthetic treatment with hyaluronic acid (HA) and/or human collagen fillers. However, a substantial increase in the frequency of AIRs was observed in the first author's… read more here.
Keywords: inflammatory reactions; human collagen; acute inflammatory; incidence ... See more keywords
Electron-Beam Irradiated Recombinant Human Collagen-Phosphorylcholine Corneal Implants Retain Pro-Regeneration Capacity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.883977
Abstract: Sterilization of biodegradable, collagen-based implants is challenging as irradiation sterilization methods can alter their mechanical properties. Electron beam (EB) irradiation is a terminal sterilization method that has been used for biologically-derived implants. Here, recombinant human… read more here.
Keywords: human collagen; collagen; recombinant human; sterilization ... See more keywords
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.876352
Abstract: Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recently, the overexpression of LH/PLODs in the tumor microenvironment… read more here.
Keywords: human collagen; hydroxylase; plod; lysyl hydroxylase ... See more keywords
Immunogenicity and Antigenicity of the Recombinant Ectodomain of Rabies Virus Glycoprotein Containing the Human Collagen XVIII Trimerization Domain
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DOI: 10.3390/vaccines13090971
Abstract: Background: Rabies remains a fatal zoonotic disease, necessitating effective and affordable vaccines. While current vaccines are effective, they require multiple doses and may not induce long-lasting immunity in all settings. The rabies virus glycoprotein (RABV-G)… read more here.
Keywords: rrabv xviii; immunogenicity; xviii; rabies virus ... See more keywords
Human collagen alpha-2 type I stimulates collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs)
Sign Up to like & getrecommendations! Published in 2020 at "BMB Reports"
DOI: 10.5483/bmbrep.2020.53.10.120
Abstract: Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal factors) and extrinsic (external environment including chronic light exposure, chemicals, and toxins) processes. These factors cause decreases in the synthesis of… read more here.
Keywords: synthesis; collagen alpha; human collagen; collagen ... See more keywords
Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
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DOI: 10.5483/bmbrep.2021.54.6.038
Abstract: Collagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure.… read more here.
Keywords: synthesis; human collagen; collagen; collagen type ... See more keywords