Biochemical and rheological analysis of human colonic culture mucus reveals similarity to gut mucus.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.10.024
Abstract: BACKGROUND AND AIMS The goal of this project was to validate the functional relevance and utility of mucus produced by an in-vitro intestinal cell culture model. This is facilitated by the need to physiologically replicate… read more here.
Keywords: gut mucus; mucus; vitro mucus; culture ... See more keywords
Microbial metabolites profile during in vitro human colonic fermentation of breakfast menus consumed by Mexican school children.
Sign Up to like & getrecommendations! Published in 2017 at "Food research international"
DOI: 10.1016/j.foodres.2017.03.038
Abstract: The nutrition transition promotes the development of childhood obesity. Currently, Mexico is affected by this serious public health problem. The nutritional and functional characterization of a whole menu has a number of advantages over the… read more here.
Keywords: vitro human; production; breakfast; fermentation ... See more keywords
Degradation of complex arabinoxylans by human colonic Bacteroidetes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20737-5
Abstract: Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified gene clusters (polysaccharide-utilization loci, PULs) for degradation of simple arabinoxylans. However, the degradation of complex… read more here.
Keywords: degradation; colonic bacteroidetes; ferulic acid; complex arabinoxylans ... See more keywords
Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18877-8
Abstract: This study investigated the effect of various prebiotics (indigestible dextrin, α-cyclodextrin, and dextran) on human colonic microbiota at a dosage corresponding to a daily intake of 6 g of prebiotics per person (0.2% of dietary intake).… read more here.
Keywords: microbiota; low amounts; colonic microbiota; amounts dietary ... See more keywords
In vitro human colonic microbiota utilises D-β-hydroxybutyrate to increase butyrogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65561-5
Abstract: The ketone body D-β-hydroxybutyrate (DBHB) has gained attention owing to its cellular signalling function; however, its effect on the human colonic microbiota remains unclear. Here, DBHB dynamics in the human colon were investigated using an… read more here.
Keywords: microbiota; microbiota models; dbhb; colonic microbiota ... See more keywords
Enteric bacteria induce IFNγ and Granzyme B from human colonic Group 1 Innate Lymphoid Cells
Sign Up to like & getrecommendations! Published in 2019 at "Gut Microbes"
DOI: 10.1080/19490976.2019.1667723
Abstract: ABSTRACT Group 1 Innate Lymphoid Cells (which include Natural Killer cells and ILC1s) aid in gut anti-bacterial defense through the production of IFNγ, which is critical for mobilizing protective responses against enteric pathogens. When intestinal… read more here.
Keywords: production; commensal; group innate; group ... See more keywords
Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.01315-19
Abstract: Due to the huge number of bacteria constituting the human colon microbiota, alteration in the balance of its constitutive taxa (i.e., dysbiosis) is highly suspected of being involved in colorectal oncogenesis. Indeed, bacterial signatures in… read more here.
Keywords: colonic crypts; microbiota; core; human colonic ... See more keywords
Genomic and epigenomic responses to aspirin in human colonic organoids.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00070.2022
Abstract: BACKGROUND Aspirin (ASA) is a proven chemoprotective agent for colorectal cancer, though mechanisms underlying these effects are incompletely understood. Human organoids are an ideal system to study genomic and epigenomic host-environment interactions. We utilize human… read more here.
Keywords: human colonic; colonic organoids; genomic epigenomic; epigenomic responses ... See more keywords
ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1072534
Abstract: Clostridioides difficile infection (CDI) causes intestinal injury. Toxin A and toxin B cause intestinal injury by inducing colonic epithelial cell apoptosis. ADS024 is a Bacillus velezensis strain in development as a single-strain live biotherapeutic product… read more here.
Keywords: human colonic; apoptosis; toxin mediated; toxin ... See more keywords
The Effect of Formulation of Curcuminoids on Their Metabolism by Human Colonic Microbiota
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25040940
Abstract: Turmeric (Curcuma longa L.) is the only edible plant recognized as a dietary source of curcuminoids, among which curcumin, demethoxycurcumin (DMC) and bis-demethoxycurcumin (Bis-DMC) are the most representative ones. Curcumin shows a very low systemic… read more here.
Keywords: curcuminoid; formulation; effect; bis ... See more keywords
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14163253
Abstract: Background: Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) patients without specific treatment. Aryl hydrocarbon receptor (AhR) activation is associated with better outcomes in intestinal inflammation. Development of novel therapies targeting fibrogenic… read more here.
Keywords: human colonic; dietary ahr; ahr ligands; tgf stimulated ... See more keywords