SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28346
Abstract: Angiogenesis, the formation of new blood vessels, is involved in a variety of diseases including the tumor growth. In response to various angiogenic stimulations, a number of proteins on the surface of vascular endothelial cells… read more here.
Keywords: vascular endothelial; snx9; surface levels; human colorectal ... See more keywords
Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3154-2
Abstract: Melatonin has antitumor activity via several mechanisms including its anti-proliferative and pro-apoptotic effects. Moreover, it has been proven that melatonin in combination with chemotherapeutic agents enhances chemotherapy-triggered apoptosis in several types of cancer. Therefore, this… read more here.
Keywords: human colorectal; melatonin increases; melatonin; adenocarcinoma cells ... See more keywords
Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.147
Abstract: Salinomycin, a polyether antibiotic, is a well-known inhibitor of human cancer stem cells. Chemical modification of the allylic C20 hydroxyl of salinomycin has enabled access to synthetic analogs that display increased cytotoxic activity compared to… read more here.
Keywords: cancer stem; colorectal cancer; human colorectal; cancer ... See more keywords
Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.05.046
Abstract: Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality… read more here.
Keywords: apoptosis; human colorectal; stress; autophagy ... See more keywords
A molecular basis for the synergy between 17‑allylamino‑17‑demethoxy geldanamycin with Capecitabine and Irinotecan in human colorectal cancer cells through VEFG and MMP-9 gene expression.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.10.016
Abstract: Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinotecan (IR) on HT-29 human colorectal carcinoma cells. Expression of MMP-9 (matrix metalloproteinase‑9) and VEGF (vascular… read more here.
Keywords: combination; demethoxy geldanamycin; allylamino demethoxy; human colorectal ... See more keywords
Photo-induced eradication of human colorectal adenocarcinoma HT-29 cells by carbon monoxide (CO) delivery from a Mn-based green luminescent photoCORM
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.09.088
Abstract: Abstract Exogenous CO delivery to cellular targets for salutary purposes can be readily achieved with photoactive metal carbonyl complexes (photoCORMs). Mn(I)-based photoCORMs are often favored for their ability to release CO upon triggering with visible… read more here.
Keywords: colorectal adenocarcinoma; luminescent photocorm; adenocarcinoma cells; human colorectal ... See more keywords
A serine protease extracted from Trichosanthes kirilowii inhibits epithelial-mesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human colorectal adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.12.001
Abstract: Abstract Trichosanthes kirilowii extract possessed various medicinal functions. Recently, it was reported that a serine protease TKP isolated from T. kirilowii inhibits human colorectal adenocarcinoma cell proliferation through inducing apoptosis. In the present study, we… read more here.
Keywords: pkm2; stat3 snail1; human colorectal; adenocarcinoma cells ... See more keywords
In situ supported of silver nanoparticles on Thymbra spicata extract coated magnetic nanoparticles under the ultrasonic condition: Its catalytic activity in the synthesis of Propargylamines and their anti-human colorectal properties in the in vitro condition
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.116451
Abstract: Abstract This work describes an eco-friendly approach for in situ immobilization of Ag nanoparticles on the surface of Fe3O4 nanoparticles, with the help of Thymbra spicata extract and ultrasound irradiations, without using any toxic reducing… read more here.
Keywords: anti human; microscopy; spectroscopy; condition ... See more keywords
Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(17)30076-6
Abstract: Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based… read more here.
Keywords: mesua ferrea; hct 116; ferrea stem; bark extract ... See more keywords
Antitumor Activity of Ohmyungsamycin A through the Regulation of the Skp2-p27 Axis and MCM4 in Human Colorectal Cancer Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00918
Abstract: Ohmyungsamycin A (1), a novel cyclic peptide discovered from a marine Streptomyces sp., was previously reported with antibacterial and anticancer activities. However, the antitumor activities and the underlying molecular mechanisms of 1 remain to be… read more here.
Keywords: colorectal cancer; human colorectal; cancer cells; cell ... See more keywords
KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15146
Abstract: Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant. While genetic mutations associated with human colorectal cancer development are well-known, little is known about how… read more here.
Keywords: cancer stem; cscs; colorectal cancer; human colorectal ... See more keywords