Functional recombinant human complement C1q with different affinity tags.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113001
Abstract: Complement C1q is a multifunctional protein able to sense pathogens and immune molecules such as immunoglobulins and pentraxins, and to trigger the classical complement pathway through activation of its two associated proteases, C1r and C1s.… read more here.
Keywords: recombinant human; complement c1q; c1q; complement ... See more keywords
Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00927
Abstract: Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound… read more here.
Keywords: c3a; c3a receptor; activity; human complement ... See more keywords
Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18937-z
Abstract: Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement… read more here.
Keywords: human complement; cr1; chagas disease; complement receptor ... See more keywords