Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice
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DOI: 10.1016/j.nbd.2017.03.006
Abstract: Catechol-O-methyltransferase (COMT) degrades dopamine and its precursor l-DOPA and plays a critical role in regulating synaptic dopamine actions. We investigated the effects of heightened levels of COMT on dopamine-regulated motor behaviors and molecular alterations in… read more here.
Keywords: human comt; confers heightened; comt; mice ... See more keywords