Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203257
Abstract: Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its proliferative… read more here.
Keywords: corneal endothelium; human corneal; corneal; nanoneedles induce ... See more keywords
PACAP through EGFR transactivation preserves human corneal endothelial integrity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28293
Abstract: The corneal endothelium is composed of a single hexagonal‐shaped cells layer adherent to the Descemet's membrane. The primary function of these cells is maintaining of tissue clarity by regulating its hydration. Trauma, aging or other… read more here.
Keywords: pacap; corneal endothelial; egfr transactivation; endothelial integrity ... See more keywords
Translational issues for human corneal endothelial tissue engineering
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2131
Abstract: Corneal endothelial disorders collectively represent a significant healthcare burden in most developed nations, and corneal transplantation is currently the only treatment available for patients with poor visual acuity and corneal blindness secondary to endothelial failure.… read more here.
Keywords: human corneal; corneal endothelial; translational issues; tissue engineering ... See more keywords
The Self-assembly Approach as a Tool for the Tissue Engineering of a Bi-lamellar Human Cornea.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0599-8_8
Abstract: Tissue engineering is a flourishing field of regenerative medicine that allows the reconstruction of various tissues of our body, including the cornea. In addition to addressing the growing need for organ transplants, such tissue-engineered substitutes… read more here.
Keywords: human corneal; cornea; tissue engineering; tissue ... See more keywords
Safety of grafting acellular human corneal lenticule seeded with Wharton's Jelly-Derived Mesenchymal Stem Cells in an experimental animal model.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108451
Abstract: The present study was conducted to evaluate safety of grafting acellular human corneal lenticule seeded with Wharton's Jelly-derived Mesenchymal Stem Cells (WJSC) in an experimental animal model. Human corneal lenticules were decellularized with a rate… read more here.
Keywords: safety grafting; human corneal; stem cells; grafting acellular ... See more keywords
Comparative quantitative assessment of the human corneal sub-basal nerve plexus by in vivo confocal microscopy and histological staining
Sign Up to like & getrecommendations! Published in 2017 at "Eye"
DOI: 10.1038/eye.2016.220
Abstract: PurposeThis study was designed to compare and contrast quantitative data of the human corneal sub-basal nerve plexus (SBP) evaluated by two different methods: in vivo confocal microscopy (IVCM), and immunohistochemical staining of ex vivo donor… read more here.
Keywords: nerve; corneal sub; microscopy; human corneal ... See more keywords
MicroRNA Profiling of Highly Enriched Human Corneal Epithelial Stem Cells by Small RNA Sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64273-0
Abstract: The objective of the study was to elucidate the microRNA (miRNA) profile of an enriched human corneal epithelial stem cell (CESC) population in comparison to differentiated central corneal epithelial cells (CCECs) by small RNA sequencing.… read more here.
Keywords: small rna; human corneal; enriched human; corneal epithelial ... See more keywords
A decellularized human corneal scaffold for anterior corneal surface reconstruction
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82678-3
Abstract: Allogenic transplants of the cornea are prone to rejection, especially in repetitive transplantation and in scarred or highly vascularized recipient sites. Patients with these ailments would particularly benefit from the possibility to use non-immunogenic decellularized… read more here.
Keywords: corneal; anterior corneal; decellularized human; corneal scaffold ... See more keywords
Knockdown of IQGAP-1 Enhances Tight Junctions and Prevents P. aeruginosa Invasion of Human Corneal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1642494
Abstract: ABSTRACT Purpose To determine the role of IQ-domain GTPase-activating protein1 (IQGAP-1) in tight junctions of human corneal epithelial cells (HCECs) and its effect against P. aeruginosa (PAK) invasion. Material and Methods Primary human corneal epithelial… read more here.
Keywords: epithelial cells; invasion; corneal epithelial; iqgap ... See more keywords
Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model
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DOI: 10.1097/ico.0000000000001555
Abstract: Purpose: To test the feasibility of a cell therapy approach to treat corneal endothelial (CE) disorders using an in vitro model of human corneal decompensation. Methods: A CE decompensation model was established by removal of… read more here.
Keywords: corneal; corneal endothelial; group; model ... See more keywords
Isolation and Characterization of a New Human Corneal Epithelial Cell Line: HCE-F.
Sign Up to like & getrecommendations! Published in 2020 at "Cornea"
DOI: 10.1097/ico.0000000000002357
Abstract: PURPOSE To isolate and characterize an epithelial cell (EC) line from a human donor cornea, which may serve as a reliable test cell line to address biomolecular issues and study the response of corneal epithelium… read more here.
Keywords: cell line; epithelial cell; line; human corneal ... See more keywords