Human coronavirus 3CL proteases cleave septins and disrupt Hedgehog signaling, causing ciliary dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28618
Abstract: Coronaviruses target ciliate cells causing the loss of cilia, acute rhinorrheas, and other ciliopathies. The loss of ciliary function may help the virus infect, replicate, and spread. However, the molecular mechanisms by which coronaviruses cause… read more here.
Keywords: 3cl protease; protease; coronavirus; human coronavirus ... See more keywords
The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.12.023
Abstract: Abstract The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope (E) protein possesses specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation,… read more here.
Keywords: protein critical; envelope protein; human coronavirus; pathology ... See more keywords
Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.1016/j.virol.2022.04.005
Abstract: Since December 2019, the deadly novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current COVID-19 pandemic. To date, vaccines are available in the developed countries to prevent the infection of this virus;… read more here.
Keywords: human coronavirus; replication; activity; flavonols dihydroflavonols ... See more keywords
Transfer efficiency of an enveloped virus, human coronavirus 229E, from various hard surface fomites to finger pads of the hands.
Sign Up to like & getrecommendations! Published in 2021 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2021.428
Abstract: Respiratory viruses can be transmitted by fomite contact, but no data currently exist on the transfer of enveloped viruses. The transfer efficiency of human coronavirus from various hard surfaces ranged from 0.46% to 49.0%. This… read more here.
Keywords: various hard; efficiency enveloped; human coronavirus; transfer efficiency ... See more keywords
Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00258
Abstract: Hexameric structure formation through packing of three C-terminal helices and an N-terminal trimeric coiled-coil core has been proposed as a general mechanism of class I enveloped virus entry. In this process, the C-terminal helical repeat… read more here.
Keywords: human coronavirus; trimeric coiled; hiv; infection ... See more keywords
Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02979
Abstract: A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination… read more here.
Keywords: andrographolide derivatives; human coronavirus; tricyclic aza; late stage ... See more keywords
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02432-7
Abstract: The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human… read more here.
Keywords: drug; coupled target; human coronavirus; analysis coupled ... See more keywords
Species‐specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults
Sign Up to like & getrecommendations! Published in 2018 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12538
Abstract: Human coronavirus (HCoV) is a known cause of influenza‐like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR‐positive for HCoV. The distribution of… read more here.
Keywords: healthy adolescents; human coronavirus; otherwise healthy; hcov ... See more keywords
Efficacy of washing produce in removing human coronavirus OC43 and murine norovirus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15667
Abstract: Fresh produce is often a vehicle for the transmission of foodborne pathogens such as human norovirus. Thus, it is recommended to wash the surface of produce before consumption, and one of the most common ways… read more here.
Keywords: murine norovirus; coronavirus; human coronavirus; coronavirus oc43 ... See more keywords
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aba9902
Abstract: The protease kallikrein 13 cleaves the spike protein of the human coronavirus HKU1 to facilitate viral entry. Priming viral entry Unlike SARS-CoV-2, the human coronavirus HKU1 normally causes relatively mild respiratory tract infections; however, it… read more here.
Keywords: hku1; hcov hku1; human coronavirus; infection ... See more keywords
Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00819-20
Abstract: Since its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in… read more here.
Keywords: human coronavirus; hcov 229e; hcov; coronavirus 229e ... See more keywords