The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition
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DOI: 10.1002/2211-5463.13454
Abstract: Highly pathogenic human coronaviruses (CoV) including SARS‐CoV, MERS‐CoV and SARS‐CoV‐2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health. The CoV surface spike (S) glycoprotein mediates… read more here.
Keywords: pathogenic human; glycoprotein; human coronaviruses; highly pathogenic ... See more keywords
Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.09.039
Abstract: Objective Uganda has registered fewer COVID-19 cases and deaths per capita than Western countries. Lower numbers of cases and deaths might be due to pre-existing cross-immunity induced by circulating common cold human coronaviruses (HCoVs) before… read more here.
Keywords: sars cov; human coronaviruses; iga reactivity; milk iga ... See more keywords
Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses
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DOI: 10.1016/j.jviromet.2020.114032
Abstract: Three highly pathogenic human coronaviruses can cause severe acute respiratory syndrome (SARS-CoV, SARS-CoV-2 and MERS-CoV). Although phylogenetic analyses have indicated ancient origin of human coronaviruses from animal relatives, their evolutionary history remains to be established.… read more here.
Keywords: comparison sars; genomic evolutionary; cov human; evolutionary comparison ... See more keywords
From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses
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DOI: 10.1016/j.meegid.2020.104502
Abstract: Abstract Human Coronaviruses (HCoV), periodically emerging across the world, are potential threat to humans such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) – diseases termed as COVID-19. Current SARS-CoV-2 outbreak have fueled ongoing efforts to… read more here.
Keywords: sars sars; insights structure; pathogenesis; cov insights ... See more keywords
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218083120
Abstract: Significance All respiratory viruses, including human coronaviruses (HCoVs), enter and establish a primary infection in the nasal epithelium. Primary nasal epithelial cells cultured at air–liquid interface (ALI) closely resemble the in vivo nasal epithelium and… read more here.
Keywords: primary nasal; infection; nasal epithelial; among lethal ... See more keywords
Is fulminant myocarditis caused by circulating human coronaviruses?
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DOI: 10.1093/eurheartj/ehaa330
Abstract: I read with interest the recent Cardiovascular Flashlight publication by Hu et al. In December 2019, a cluster of pneumonia cases of unknown aetiology were identified in Wuhan, Hebei, China caused by a novel coronavirus,… read more here.
Keywords: coronavirus; fulminant myocarditis; respiratory; sars cov ... See more keywords
HLA‐dependent variation in SARS‐CoV‐2 CD8 + T cell cross‐reactivity with human coronaviruses
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DOI: 10.1111/imm.13451
Abstract: The conditions and extent of cross‐protective immunity between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) remain open despite several reports of pre‐existing T cell immunity to SARS‐CoV‐2 in individuals without… read more here.
Keywords: cell; cov peptides; human coronaviruses; cross ... See more keywords
The Stability of Model Human Coronaviruses on Textiles in the Environment and during Health Care Laundering
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DOI: 10.1128/msphere.00316-21
Abstract: Synthetic textiles such as polyester could potentially act as fomites of human coronaviruses, indicating the importance of infection control procedures during handling of contaminated textiles prior to laundering. This study provides novel evidence that human… read more here.
Keywords: laundering; human coronaviruses; hcov oc43; health care ... See more keywords
Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19
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DOI: 10.1186/s12916-020-01887-1
Abstract: Background Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we explore the potential role of cross-reactivity… read more here.
Keywords: age; exposure; severity; endemic human ... See more keywords
Etiology and clinical characteristics of SARS-CoV-2 and other human coronaviruses among children in Zhejiang Province, China 2017–2019
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DOI: 10.1186/s12985-021-01562-8
Abstract: Background A novel coronavirus (SARS-CoV-2) emerging has put global public health institutes on high alert. Little is known about the epidemiology and clinical characteristics of human coronaviruses infections in relation to infections with other respiratory… read more here.
Keywords: clinical characteristics; etiology; specimens hcov; sars cov ... See more keywords
Human coronaviruses and therapeutic drug discovery
Sign Up to like & getrecommendations! Published in 2021 at "Infectious Diseases of Poverty"
DOI: 10.1186/s40249-021-00812-9
Abstract: Background Coronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs). Although HCoV-specific drugs are still lacking, many potent targets for drug discovery are being explored, and… read more here.
Keywords: drug; therapeutic drug; clinical trials; drug discovery ... See more keywords