Human cortical amygdala dendrites and spines morphology under open‐source three‐dimensional reconstruction procedures
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25430
Abstract: Visualizing nerve cells has been fundamental for the systematic description of brain structure and function in humans and other species. Different approaches aimed to unravel the morphological features of neuron types and diversity. The inherent… read more here.
Keywords: human cortical; reconstruction; cortical amygdala; dendrites spines ... See more keywords
Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.27451
Abstract: To detect microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding experiments. read more here.
Keywords: microscopic diffusion; diffusion; diffusion anisotropy; human cortical ... See more keywords
M89 MODELING HUMAN CORTICAL BRAIN DEVELOPMENT BY THE GENERATION OF CEREBRAL ORGANOIDS FROM PATIENT-SPECIFIC STEM CELLS FOR THE ANALYSIS OF SCHIZOPHRENIA GENETICS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.396
Abstract: Background Characteristics of schizophrenia include the deregulation of the glutamatergic and the GABAergic neurotransmission and the degeneration of predominantly inhibitory interneurons within the cortex of the human brain. Cortical development was extensively studied in rodents,… read more here.
Keywords: patient specific; ips cells; analysis; human cortical ... See more keywords
Raman spectroscopic determination of bone matrix quantity and quality augments prediction of human cortical bone mechanical properties.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2021.110342
Abstract: Being independent contributors to bone mechanical resistance at the apparent level, quality and quantity of bone primary constituents are essential factors in better fracture risk assessment. Raman spectroscopy (RS) holds great potential for being a… read more here.
Keywords: quality; derived measurements; human cortical; quantity ... See more keywords
Improving human cortical sulcal curve labeling in large scale cross-sectional MRI using deep neural networks
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2019.108311
Abstract: BACKGROUND Human cortical primary sulci are relatively stable landmarks and commonly observed across the population. Despite their stability, the primary sulci exhibit phenotypic variability. NEW METHOD We propose a fully automated pipeline that integrates both… read more here.
Keywords: curve labeling; neural networks; sulcal curve; human cortical ... See more keywords
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28043-y
Abstract: Microglia play a role in the emergence and preservation of a healthy brain microenvironment. Dysfunction of microglia has been associated with neurodevelopmental and neurodegenerative disorders. Investigating the function of human microglia in health and disease… read more here.
Keywords: transcription factor; cortical organoids; expression; human cortical ... See more keywords
Induction of Myelinating Oligodendrocytes in Human Cortical Spheroids
Sign Up to like & getrecommendations! Published in 2018 at "Nature methods"
DOI: 10.1038/s41592-018-0081-4
Abstract: Cerebral organoids provide an accessible system for investigations of cellular composition, interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we reproducibly generated oligodendrocytes and myelin in ‘oligocortical… read more here.
Keywords: induction myelinating; system; human cortical; oligodendrocytes human ... See more keywords
Tropism of SARS-CoV-2 for human cortical astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122236119
Abstract: Significance Neurological and neuropsychiatric symptoms occur in as many as one-third of patients with or recovering from COVID-19. To address severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neural tropism, we evaluated the vulnerability of primary… read more here.
Keywords: cortical astrocytes; infection; human cortical; tropism sars ... See more keywords
Direct Generation of Human Cortical Organoids from Primary Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2018.0112
Abstract: The study of variations in human neurodevelopment and cognition is limited by the availability of experimental models. While animal models only partially recapitulate the human brain development, genetics, and heterogeneity, human-induced pluripotent stem cells can… read more here.
Keywords: direct generation; human cortical; generation human; cortical organoids ... See more keywords
Age-Dependent Changes in Synaptic NMDA Receptor Composition in Adult Human Cortical Neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa052
Abstract: The molecular processes underlying the aging-related decline in cognitive performance and memory observed in humans are poorly understood. Studies in rodents have shown a decrease in N-methyl-D-aspartate receptors (NMDARs) that contain the GluN2B subunit in… read more here.
Keywords: age dependent; glun2b; adult human; age ... See more keywords
Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhx309
Abstract: The cerebral cortex may be organized into anatomical genetic modules, communities of brain regions with shared genetic influences via pleiotropy. Such modules could represent novel phenotypes amenable to large-scale gene discovery. This modular structure was… read more here.
Keywords: thickness organized; human cortical; organized genetically; cortical thickness ... See more keywords