Structural and functional characterization of a missense mutant of human γS-crystallin associated with dominant infantile cataracts.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.187
Abstract: Infantile cataracts constitute one of the most important causes of childhood blindness worldwide. Human γS-crystallin is the most abundant protein in the eye lens cortex. A missense mutant of human γS-crystallin, Y67N (abbreviated hereafter as… read more here.
Keywords: infantile cataracts; missense mutant; mutant human; structural functional ... See more keywords
On identifying low energy conformational excited states with differential ruggedness in human γS-crystallin promoting severe infantile cataracts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.071
Abstract: Transient excited states in proteins can be accurately probed from temperature dependence of amide proton (1HN) chemical shifts displaying significant curvatures. Characterizing these near-native alternative states is of high therapeutic relevance in conformational diseases wherein… read more here.
Keywords: ruggedness human; energy; infantile cataracts; excited states ... See more keywords
The Y46D Mutation Destabilizes Dense Packing of the Second Greek Key Pair of Human γC-Crystallin Causing Congenital Nuclear Cataracts.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00628
Abstract: The γ-crystallins are highly expressed structural lens proteins comprising four Greek key motifs arranged in two domains. Their globular structure and short-range spatial ordering are essential for lens transparency. Aromatic residues play a vital role… read more here.
Keywords: y46d mutation; crystallin; greek key; spectroscopy ... See more keywords
Elucidation of molecular interactions between human γD-crystallin and quercetin, an inhibitor against tryptophan oxidation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1738960
Abstract: Abstract Different post-translational changes in eye lens crystallin proteins contribute towards the development of cataract. We have studied in vitro oxidative modification of tryptophan (Trp) residues of human γD-crystallin (HGD) towards formation of N-formylkynurenine (NFK)… read more here.
Keywords: oxidation; molecular interactions; elucidation molecular; quercetin ... See more keywords