Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach
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DOI: 10.1080/19420862.2018.1462429
Abstract: ABSTRACT The linear pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) can be considered a class property with values that are similar to endogenous IgG. Knowledge of these parameters across species could be used to avoid… read more here.
Keywords: poppk; monoclonal antibodies; human cynomolgus; cynomolgus monkey ... See more keywords