An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae
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DOI: 10.1002/em.22093
Abstract: P450 activity is required to metabolically activate many chemical carcinogens, rendering them highly genotoxic. CYP3A4 is the most abundantly expressed P450 enzyme in the liver, accounting for most drug metabolism and constituting 50% of all… read more here.
Keywords: saccharomyces cerevisiae; genotoxicity; human cyp3a4; yeast ... See more keywords