The effect of three polyphenols and some other antioxidant substances on amyloid fibril formation by Human cystatin C
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104806
Abstract: Human cystatin C (CysC) is an amyloid forming protein involved in the hereditary cerebral amyloid angiopathy (HCCAA) that affects arteries in the brain and the peripheral nervous system. In this study we measured the influence… read more here.
Keywords: human cystatin; effect; fibril formation; effect three ... See more keywords
Is the absence of alpha-helix 2 in the appendant structure region the major contributor to structural instability of human cystatin C?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1552625
Abstract: Human cystatin C (HCC) is a 120-amino acid protein that belongs to the cystatin super family. It is expressed in all nucleated human cells and is found in almost all tissues and body fluids. HCC… read more here.
Keywords: absence alpha; human cystatin; cystatin; structure ... See more keywords
Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers
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DOI: 10.3390/ijms21165860
Abstract: Human cystatin C (HCC), a cysteine-protease inhibitor, exists as a folded monomer under physiological conditions but has the ability to self-assemble via domain swapping into multimeric states, including oligomers with a doughnut-like structure. The structure… read more here.
Keywords: hcc; stab hcc; microscopy; human cystatin ... See more keywords
Identification of a Steric Zipper Motif in the Amyloidogenic Core of Human Cystatin C and Its Use for the Design of Self-Assembling Peptides
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DOI: 10.3390/ijms23105800
Abstract: Amyloid fibrils have been known for many years. Unfortunately, their fame stems from negative aspects related to amyloid diseases. Nevertheless, due to their properties, they can be used as interesting nanomaterials. Apart from their remarkable… read more here.
Keywords: zipper; human cystatin; steric zipper; use ... See more keywords
Oligomerization of Human Cystatin C—An Amyloidogenic Protein: An Analysis of Small Oligomeric Subspecies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113441
Abstract: Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetramers and donut like large oligomers) via a domain-swapping mechanism. The aim of this study was the characterization of the HCC oligomeric… read more here.
Keywords: oligomerization human; hcc; amyloidogenic protein; human cystatin ... See more keywords