8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200334
Abstract: Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have previously shown that pUL89‐C can be pharmacologically inhibited with designed metal‐chelating compounds. We… read more here.
Keywords: pul89; human cytomegalovirus; hydroxy naphthyridine; endonuclease ... See more keywords
A systematic review and meta‐analysis of the prevalence of human cytomegalovirus shedding in seropositive pregnant women
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DOI: 10.1002/rmv.2399
Abstract: The detection of human cytomegalovirus (HCMV) in an individual's bodily fluid by culture techniques or through HCMV DNA detection by polymerase chain reaction, is known as HCMV shedding. Human cytomegalovirus shedding has the potential to… read more here.
Keywords: hcmv shedding; hcmv seropositive; infection; hcmv ... See more keywords
Human Hematopoietic Long-Term Culture (hLTC) for Human Cytomegalovirus Latency and Reactivation.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1111-1_5
Abstract: Of the many research challenges posed by the study of human cytomegalovirus (HCMV) latency, one of the most notable is the requirement for the use of primary hematopoietic cell culture. Culturing hematopoietic progenitor subpopulations requires that… read more here.
Keywords: latency; long term; reactivation; human cytomegalovirus ... See more keywords
Construction of Human Cytomegalovirus Mutants with Markerless BAC Mutagenesis.
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DOI: 10.1007/978-1-0716-1111-1_8
Abstract: To fully understand the function of cytomegalovirus (CMV) genes, it is imperative that they are studied in the context of infection. Therefore, the targeted deletion of individual viral genes and the comparison of these loss-of-function… read more here.
Keywords: mutagenesis; cytomegalovirus mutants; human cytomegalovirus; construction human ... See more keywords
Targeting human cytomegalovirus IE genes by CRISPR/Cas9 nuclease effectively inhibits viral replication and reactivation
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04687-3
Abstract: Human cytomegalovirus (HCMV) infection causes high morbidity and mortality among immunocompromised patients and can remain in a latent state in host cells. Expression of the immediate-early (IE) genes sustains HCMV replication and reactivation. As a… read more here.
Keywords: reactivation; crispr cas9; human cytomegalovirus; replication reactivation ... See more keywords
The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00106-3
Abstract: As a universal pathogen leading to neonatal defects and transplant failure, human cytomegalovirus (HCMV) has strict species specificity and this has prevented the development of a suitable animal model for the pathogenesis study. The mechanism… read more here.
Keywords: susceptibility primary; dermis fibroblasts; tree shrew; chinese tree ... See more keywords
Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro
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DOI: 10.1007/s12275-020-9528-2
Abstract: Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there… read more here.
Keywords: infection; hcmv; human cytomegalovirus; cytomegalovirus hcmv ... See more keywords
A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.07.012
Abstract: Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential association of HCMV antibodies targeting… read more here.
Keywords: sclerosis; ssc; antigen specific; human cytomegalovirus ... See more keywords
Reactivation of human cytomegalovirus inhibits expression of liver fibrosis related cytokines in patients chronically infected with hepatitis C virus genotype 4a.
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DOI: 10.1016/j.micpath.2020.104596
Abstract: BACKGROUND The impact of human cytomegalovirus (HCMV) reactivation on the expression pattern of matrix metalloproteinases, their inhibitors and related cytokines during HCV infection poorly understood. METHODS Reactivation of CMV in 95 subjects (75 chronically infected… read more here.
Keywords: related cytokines; reactivation; fibrosis related; human cytomegalovirus ... See more keywords
mir-155 expression is downregulated in kidney transplant patients with human cytomegalovirus infection.
Sign Up to like & getrecommendations! Published in 2017 at "Transplant immunology"
DOI: 10.1016/j.trim.2017.06.002
Abstract: MicroRNAs are small, noncoding RNAs that control expression of target genes through inhibiting protein translation or inducing degradation of mRNA transcripts of target genes. According to the latest update, 2578 unique mature miRNAs are currently… read more here.
Keywords: mir 155; infection; transplant; human cytomegalovirus ... See more keywords
Human Papillomavirus and Human Cytomegalovirus Infection and Association with Prognosis in Patients with Primary Glioblastoma in Pakistan.
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.10.018
Abstract: OBJECTIVE Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. Human cytomegalovirus (HCMV) has been studied for the past decade, and conflicting results have been reported with no conclusive role established yet. Human… read more here.
Keywords: gbm; infection; human cytomegalovirus; hpv ... See more keywords