Human β-Defensin 118 Attenuates Escherichia coli K88–Induced Inflammation and Intestinal Injury in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Probiotics and Antimicrobial Proteins"
DOI: 10.1007/s12602-020-09725-9
Abstract: Antibiotics are widely used to treat various inflammatory bowel diseases caused by enterotoxigenic Escherichia coli (ETEC). However, continuous use of antibiotics may lead to drug resistance. In this study, we investigated the role of human… read more here.
Keywords: inflammation intestinal; induced inflammation; escherichia coli; defensin 118 ... See more keywords
A high affinity modified DNA aptamer containing base-appended bases for human β-defensin.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113627
Abstract: We used base-appended base modification to develop a new adenine analog, which incorporates an adenine derivative at position 7 of adenine. Using the systematic evolution of ligands by exponential enrichment method with a modified DNA… read more here.
Keywords: high affinity; base; human defensin; base appended ... See more keywords
Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.6b00653
Abstract: Human α-defensin 6 (HD6) is a 32-residue cysteine-rich peptide that contributes to innate immunity by protecting the host at mucosal sites. This peptide is produced in small intestinal Paneth cells, stored as an 81-residue precursor… read more here.
Keywords: hd6; peptide self; self assembles; host ... See more keywords
Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oral Science"
DOI: 10.1038/s41368-020-0078-6
Abstract: Efforts to control inflammation and achieve better tissue repair in the treatment of periodontitis have been ongoing for years. Human β-defensin 3, a broad-spectrum antimicrobial peptide has been proven to have a variety of biological… read more here.
Keywords: bone repair; human defensin; defensin; defensin gene ... See more keywords
Integrated solid-state NMR and molecular dynamics modeling determines membrane insertion of human β-defensin analog
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0653-6
Abstract: Human β-defensins (hBD) play central roles in antimicrobial activities against various microorganisms and in immune-regulation. These peptides perturb phospholipid membranes for function, but it is not well understood how defensins approach, insert and finally disrupt… read more here.
Keywords: solid state; defensin; state nmr; human defensin ... See more keywords
Human defensin-inspired discovery of peptidomimetic antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117283119
Abstract: Significance We report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with… read more here.
Keywords: peptidomimetic antibiotics; inspired discovery; discovery peptidomimetic; defensin inspired ... See more keywords
Therapeutic Potential of Synthetic Human β-Defensin 1 Short Motif Pep-B on Lipopolysaccharide-Stimulated Human Dental Pulp Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/6141967
Abstract: Dental pulp inflammation is a widespread public problem usually caused by caries or trauma. Alleviating inflammation is critical to inflamed pulp repair. Human β-defensin 1 short motif Pep-B is a cationic peptide that has anti-inflammatory,… read more here.
Keywords: dental pulp; defensin short; short motif; pulp ... See more keywords
Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria.
Sign Up to like & getrecommendations! Published in 2021 at "International archives of allergy and immunology"
DOI: 10.1159/000516952
Abstract: INTRODUCTION Chronic spontaneous urticaria (CSU) is a common cutaneous disease caused by mast-cell degranulation. Human β-defensin 2 (HBD2) is a well-known antimicrobial peptide that is also a pruritogen inducing vascular permeability via non-IgE-mediated mast-cell degranulation.… read more here.
Keywords: spontaneous urticaria; chronic spontaneous; csu; human defensin ... See more keywords
Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD
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DOI: 10.1371/journal.pone.0175963
Abstract: Viral-bacterial co-infections are associated with severe exacerbations of COPD. Epithelial antimicrobial peptides, including human β-defensin-2 (HBD-2), are integral to innate host defenses. In this study, we examined how co-infection of airway epithelial cells with rhinovirus… read more here.
Keywords: epithelial cells; production; hbd; infection ... See more keywords
Activation and Biological Properties of Human β Defensin 4 in Stem Cells Derived From Human Exfoliated Deciduous Teeth
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01304
Abstract: Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This… read more here.
Keywords: cells derived; hbd4; human exfoliated; human defensin ... See more keywords
Potential Application of Human β-Defensin 4 in Dental Pulp Repair
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.01077
Abstract: When pulp tissue is damaged by caries or trauma, vital pulp therapy (VPT) can help preserve the pulp tissue for long-term retention of teeth. However, the choice of pulp capping agent used in VPT is… read more here.
Keywords: dpsc; hbd4; dental pulp; human defensin ... See more keywords