OMIP‐44: 28‐Color Immunophenotyping of the Human Dendritic Cell Compartment
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23854
Abstract: This work describes the first 30-parameter immunophenotyping of the human dendritic cell (DC) compartment using fluorescent-based flow cytometry. The optimized panel allows for simultaneous detection of 21 myeloid-centric markers distinguishing all canonical DC subsets, with… read more here.
Keywords: immunophenotyping human; human dendritic; cell compartment; dendritic cell ... See more keywords
Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747024
Abstract: Recurrent respiratory tract infections (RRTIs) are the first leading cause of community‐ and nosocomial‐acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches… read more here.
Keywords: signalling pathways; responses via; dendritic cells; th1 th17 ... See more keywords
Human dendritic cell subsets: an updated view of their ontogeny and functional specialization.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149632
Abstract: Human dendritic cells (DC) have been divided into several subsets based on their phenotype and ontogeny. Recent high throughput single-cell methods have revealed additional heterogeneity within human DC subsets, and new subpopulations have been proposed.… read more here.
Keywords: updated view; functional specialization; cell; human dendritic ... See more keywords
The effects of CCR7 and related signaling pathways on Leishmania major ‐infected human dendritic cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27985
Abstract: In our research, we aimed to investigate the roles of CC‐chemokine receptor 7 (CCR7) and relevant signaling pathways in Leishmania major‐infected human dendritic cells (DCs). read more here.
Keywords: signaling pathways; leishmania major; pathways leishmania; major infected ... See more keywords
2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107652
Abstract: Human health can be affected by materials indirectly through exposure to the environment or directly through close contact and uptake. With the ever-growing use of 2D materials in many applications such as electronics, medical therapeutics,… read more here.
Keywords: primary human; materials primary; human dendritic; cells comparative ... See more keywords
A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.012
Abstract: Cell-cell communication involves a large number of molecular signals that function as words of a complex language whose grammar remains mostly unknown. Here, we describe an integrative approach involving (1) protein-level measurement of multiple communication… read more here.
Keywords: communication; model; dendritic cell; human dendritic ... See more keywords
Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108180
Abstract: SUMMARY Human dendritic cells (DCs) comprise subsets with distinct phenotypic and functional characteristics, but the transcriptional programs that dictate their identity remain elusive. Here, we analyze global chromatin accessibility profiles across resting and stimulated human… read more here.
Keywords: chromatin; heterogeneity; chromatin landscape; chromatin accessibility ... See more keywords
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-018-0161-5
Abstract: We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the… read more here.
Keywords: fibrosis; transgenic mice; renal fibrosis; human dendritic ... See more keywords
Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-3551
Abstract: α-Fetoprotein (AFP) is a secreted tumor protein and biomarker with impact on immunity. Fatty acid–bound AFP promotes immune suppression by skewing human dendritic cell metabolism toward glycolysis and reduced immune stimulation. read more here.
Keywords: immune suppression; human dendritic; promotes immune; acid bound ... See more keywords
Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an “all-or-nothing” communication switch between the spine head and dendrite
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010069
Abstract: Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle, composed of… read more here.
Keywords: human dendritic; calcium; spine apparatus; dendritic spines ... See more keywords
Visualization of early influenza A virus trafficking in human dendritic cells using STED microscopy
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0177920
Abstract: Influenza A viruses (IAV) primarily target respiratory epithelial cells, but can also replicate in immune cells, including human dendritic cells (DCs). Super-resolution microscopy provides a novel method of visualizing viral trafficking by overcoming the resolution… read more here.
Keywords: trafficking human; microscopy; influenza; dendritic cells ... See more keywords