Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α
Sign Up to like & getrecommendations! Published in 2017 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-017-1541-1
Abstract: BackgroundBack pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently known about the presence or… read more here.
Keywords: human disc; muc1; exposure; tissue ... See more keywords
Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism
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DOI: 10.3390/ijms22083965
Abstract: The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components under stress, primarily nutrient deprivation. Resident cells would utilize autophagy to cope with the… read more here.
Keywords: disc cellular; apoptosis senescence; human disc; autophagy ... See more keywords