Lipid rafts and human diseases: why we need to target gangliosides.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13612
Abstract: Gangliosides are functional components of membrane lipid rafts that control critical functions in cell communication. Many pathologies involve raft gangliosides, which therefore represent an approach of choice for developing innovative therapeutic strategies. Beginning with a… read more here.
Keywords: need target; gbd gbd; lipid rafts; human diseases ... See more keywords
Fasting: From Physiology to Pathology
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204487
Abstract: Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting… read more here.
Keywords: fasting physiology; human diseases; pathology; physiology ... See more keywords
Emerging roles of alternative cleavage and polyadenylation (APA) in human disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30549
Abstract: In the messenger RNA (mRNA) maturation process, the 3'-end of pre-mRNA is cleaved and a poly(A) sequence is added, this is an important determinant of mRNA stability and its cellular functions. More than 60%-70% of… read more here.
Keywords: cleavage polyadenylation; polyadenylation apa; polyadenylation; alternative cleavage ... See more keywords
Emerging trends of edible vaccine therapy for combating human diseases especially COVID‐19: Pros, cons, and future challenges
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7475
Abstract: The researchers are still doing efforts to develop an effective, reliable, and easily accessible vaccine candidate to protect against COVID‐19. As of the August 2020, nearly 30 conventional vaccines have been emerged in clinical trials,… read more here.
Keywords: diseases especially; emerging trends; human diseases; trends edible ... See more keywords
MicroRNAs in Genetic Etiology of Human Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1170-8_13
Abstract: Since their first discovery more than 20 years ago, miRNAs have been subject to deliberate research and analysis for revealing their physiological or pathological involvement. Regulatory roles of miRNAs in signal transduction, gene expression, and cellular… read more here.
Keywords: etiology human; etiology; biology; micrornas genetic ... See more keywords
Solutions against emerging infectious and noninfectious human diseases through the application of baculovirus technologies
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-021-11615-1
Abstract: Abstract Baculoviruses are insect pathogens widely used as biotechnological tools in different fields of life sciences and technologies. The particular biology of these entities (biosafety viruses 1; large circular double-stranded DNA genomes, infective per se;… read more here.
Keywords: noninfectious human; application; baculovirus; biology ... See more keywords
Role of formin INF2 in human diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06869-x
Abstract: Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal… read more here.
Keywords: inf2 human; biology; formin; human diseases ... See more keywords
Generation of genetically-engineered animals using engineered endonucleases
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1037-z
Abstract: The key to successful drug discovery and development is to find the most suitable animal model of human diseases for the preclinical studies. The recent emergence of engineered endonucleases is allowing for efficient and precise… read more here.
Keywords: genetically engineered; engineered endonucleases; generation genetically; human diseases ... See more keywords
Epigenetic related changes on air quality.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental research"
DOI: 10.1016/j.envres.2021.111155
Abstract: The exposure to airborne particulate matter (PM) increases the risk of developing human diseases. Epigenetic mechanisms have been related to environmental exposures and human diseases. The present review is focused on current available studies, which… read more here.
Keywords: changes air; related changes; epigenetic related; air ... See more keywords
The aberrant expression or disruption of desmocollin2 in human diseases.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.03.041
Abstract: The desmosome is a member of intercellular junctions that named 'anchoring junction', which contributes to the integrity and homeostasis of tissue structure and function of multicellular living organisms. As an important component of the desmosome… read more here.
Keywords: aberrant expression; human diseases; dsc2; expression disruption ... See more keywords
Recent advancement on development of drug-induced macrophage polarization in control of human diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119914
Abstract: Macrophages, an important part of human immune system, possess a high plasticity and heterogeneity (macrophage polarization) as classically activated macrophages (M1) and alternatively activated macrophages (M2), which exert pro-inflammatory/anti-tumor and anti-inflammatory/pro-tumor effects, respectively. Thus, drug… read more here.
Keywords: macrophage polarization; polarization; drug; recent advancement ... See more keywords