Human DNA helicase, RuvBL1 and its Chlamydomonas homologue, CrRuvBL1 plays an important role in ciliogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21377
Abstract: Several nuclear and nucleic acid‐binding proteins were detected in the proteomic analyses of ciliary fractions from various organisms. Yet very little is known about the role of these proteins in ciliogenesis and ciliary signaling. In… read more here.
Keywords: dna helicase; human dna; important role; role ciliogenesis ... See more keywords
Quantification of deoxythioguanosine in human DNA with LC-MS/MS, a marker for thiopurine therapy optimisation
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05581-6
Abstract: In the treatment of diseases such as acute childhood leukaemia (ALL) and inflammatory bowel disease (IBD), the thiopurines azathioprine, 6-mercaptopurine, and 6-thioguanine are used. Thiopurines are antimetabolites and immunomodulators used to maintain remission in patients.… read more here.
Keywords: deoxythioguanosine; deoxythioguanosine human; quantification deoxythioguanosine; dtg ... See more keywords
Epigenetically modified N6-methyladenine inhibits DNA replication by human DNA polymerase η.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.03.015
Abstract: N6-methyladenine (6mA), as a newly reported epigenetic marker, plays significant roles in regulation of various biological processes in eukaryotes. However, the effect of 6mA on human DNA replication remain elusive. In this work, we used… read more here.
Keywords: dna; human dna; dna replication; dna polymerase ... See more keywords
Isolation, identification, and time course of human DNA typing from bed bugs, Cimex lectularius.
Sign Up to like & getrecommendations! Published in 2018 at "Forensic science international"
DOI: 10.1016/j.forsciint.2018.10.008
Abstract: Bed bugs (Cimex lectularius L.) are ectoparasitic wingless insects that feed on the blood of mammals, typically in residential settings. The objectives of this study were to establish a time-course of human DNA quantitation from… read more here.
Keywords: human dna; time; bed bug; blood ... See more keywords
Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η
Sign Up to like & getrecommendations! Published in 2024 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00569
Abstract: Urea lesions in DNA arise from thymine glycol (Tg) or 8-oxo-dG; their genotoxicity is thought to arise in part due to their potential to accommodate the insertion of all four dNTPs during error-prone replication. Replication… read more here.
Keywords: replication bypass; replication; urea lesions; human dna ... See more keywords
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01869
Abstract: Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mechanism limits their utility.… read more here.
Keywords: transition state; dna; dna methyltransferase; human dna ... See more keywords
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01142
Abstract: Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other DNA repair pathway defective cancers.… read more here.
Keywords: small molecule; dna polymerase; dna; vivo ... See more keywords
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-55772-z
Abstract: Human DNA licensing initiates the process of replication fork assembly. Specifically, this reaction leads to the loading of hMCM2-7 on DNA, which represents the core of the replicative helicase that unwinds DNA during S-phase. Here,… read more here.
Keywords: analysis; human dna; dna licensing; structural functional ... See more keywords
Codon usage of human DNA viruses and its similarity to certain host genes
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-27070-1
Abstract: Codon usages of DNA viruses had previously been shown to associate with their genome size. Codon usage of various human DNA viruses was compared to those of human genes to further understand viral codon usage… read more here.
Keywords: dna viruses; human dna; codon usage;
A specific autoantibody against a novel tumour-association antigen derived from human DNA-topoiomerase I is a potential biomarker for early diagnosis and favourable prognosis in patients with colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Biomarkers"
DOI: 10.1080/1354750x.2020.1714734
Abstract: Abstract Context: We previously reported a novel tumour associated antigen (TTA) with molecular weight around 48 kDa and identified the novel TTA as a fragment derived from human DNA-topoiomerase I (TOP1). We termed the novel TAA… read more here.
Keywords: autoantibody; novel tumour; dna topoiomerase; patients colorectal ... See more keywords
From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2078320
Abstract: Abstract Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the identification of a natural compound, membranoid G, derived from the Antarctic sponge… read more here.
Keywords: antarctic sponge; dna; dendrilla antarctica; sponge dendrilla ... See more keywords