Human DNA helicase, RuvBL1 and its Chlamydomonas homologue, CrRuvBL1 plays an important role in ciliogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21377
Abstract: Several nuclear and nucleic acid‐binding proteins were detected in the proteomic analyses of ciliary fractions from various organisms. Yet very little is known about the role of these proteins in ciliogenesis and ciliary signaling. In… read more here.
Keywords: dna helicase; human dna; important role; role ciliogenesis ... See more keywords
Epigenetically modified N6-methyladenine inhibits DNA replication by human DNA polymerase η.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.03.015
Abstract: N6-methyladenine (6mA), as a newly reported epigenetic marker, plays significant roles in regulation of various biological processes in eukaryotes. However, the effect of 6mA on human DNA replication remain elusive. In this work, we used… read more here.
Keywords: dna; human dna; dna replication; dna polymerase ... See more keywords
Isolation, identification, and time course of human DNA typing from bed bugs, Cimex lectularius.
Sign Up to like & getrecommendations! Published in 2018 at "Forensic science international"
DOI: 10.1016/j.forsciint.2018.10.008
Abstract: Bed bugs (Cimex lectularius L.) are ectoparasitic wingless insects that feed on the blood of mammals, typically in residential settings. The objectives of this study were to establish a time-course of human DNA quantitation from… read more here.
Keywords: human dna; time; bed bug; blood ... See more keywords
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01869
Abstract: Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mechanism limits their utility.… read more here.
Keywords: transition state; dna; dna methyltransferase; human dna ... See more keywords
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01142
Abstract: Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other DNA repair pathway defective cancers.… read more here.
Keywords: small molecule; dna polymerase; dna; vivo ... See more keywords
A specific autoantibody against a novel tumour-association antigen derived from human DNA-topoiomerase I is a potential biomarker for early diagnosis and favourable prognosis in patients with colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Biomarkers"
DOI: 10.1080/1354750x.2020.1714734
Abstract: Abstract Context: We previously reported a novel tumour associated antigen (TTA) with molecular weight around 48 kDa and identified the novel TTA as a fragment derived from human DNA-topoiomerase I (TOP1). We termed the novel TAA… read more here.
Keywords: autoantibody; novel tumour; dna topoiomerase; patients colorectal ... See more keywords
From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2078320
Abstract: Abstract Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the identification of a natural compound, membranoid G, derived from the Antarctic sponge… read more here.
Keywords: antarctic sponge; dna; dendrilla antarctica; sponge dendrilla ... See more keywords
Structural basis for the D-stereoselectivity of human DNA polymerase β
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx252
Abstract: Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) with L-stereochemistry have long been an effective treatment for viral infections because of the strong D-stereoselectivity exhibited by human DNA polymerases relative to viral reverse transcriptases. The D-stereoselectivity of… read more here.
Keywords: dna; human dna; dna polymerases; dna polymerase ... See more keywords
Three assays for in-solution enrichment of ancient human DNA at more than a million SNPs
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276728.122
Abstract: The strategy of in-solution enrichment for hundreds of thousands of single-nucleotide polymorphisms (SNPs) has been used to analyze >70% of individuals with genome-scale ancient DNA published to date. This approach makes it economical to study… read more here.
Keywords: million snps; dna; three assays; snps ... See more keywords
Human DNA contamination of postmortem examination facilities: Impact of COVID‐19 cleaning procedure
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15096
Abstract: The DNA contamination of evidentiary trace samples, included those collected in the autopsy room, has significant detrimental consequences for forensic genetics investigation. After the COVID‐19 pandemic, methods to prevent environmental contamination in the autopsy room… read more here.
Keywords: dna; dna contamination; postmortem examination; contamination ... See more keywords
Assessing the use of environmental DNA (eDNA) as a tool in the detection of human DNA in water
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15124
Abstract: Environmental DNA (eDNA) is a highly sensitive and cost‐effective tool that is increasingly being applied to studies of biodiversity and species detection. This non‐invasive method relies on the collection of environmental samples that contain genetic… read more here.
Keywords: dna edna; dna; water; detection ... See more keywords