Mitochondrial function of human embryo: Decline in their quality with maternal aging
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12491
Abstract: Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo. read more here.
Keywords: function; human embryo; embryo decline; function human ... See more keywords
The role of microRNAs in human embryo implantation: a review
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-018-1326-y
Abstract: MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we present here a review of the literature from a clinical perspective. Implantation involves complex interactions between the blastocyst and endometrium. miRNAs have been… read more here.
Keywords: embryo implantation; endometrium; review; human embryo ... See more keywords
Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.12.008
Abstract: Over the past few years, a number of research groups have reported striking progress on the generation of in vitro models from mouse and human stem cells that replicate aspects of early embryonic development. Not… read more here.
Keywords: guidelines research; toward guidelines; research; human embryo ... See more keywords
Are we ready to genetically modify a human embryo? Or is it too late to ask?
Sign Up to like & getrecommendations! Published in 2019 at "Accountability in Research"
DOI: 10.1080/08989621.2019.1617139
Abstract: ABSTRACT After the announcement that a scientist genetically altered human embryos and implanted them for gestation last November, the increased discussion has revolved around the ethical lapses that occurred in the process. The scientist, He… read more here.
Keywords: ready genetically; genetically modify; research; human embryo ... See more keywords
Sialyl Lewis X mediates interleukin-1 beta-induced trophoblast adhesion to endometrial cells during human embryo implantation
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad007
Abstract: Abstract Cell surface carbohydrate antigens sialyl Lewis X (sLeX) and Lewis Y (LeY) are paramount glycoconjugates and are abundantly expressed in the receptive endometrium. Furthermore, among the important biological functions of both antigens is their… read more here.
Keywords: human embryo; beta; trophoblast adhesion; expression ... See more keywords
Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Human Reproduction"
DOI: 10.1093/molehr/gay011
Abstract: Abstract STUDY QUESTION Which set of antibodies can be used to identify migratory and early post-migratory human primordial germ cells (hPGCs)? STUDY FINDING We validated the specificity of 33 antibodies for 31 markers, including POU5F1,… read more here.
Keywords: study; germ cells; expression; human embryo ... See more keywords
Regional and developmental characteristics of human embryo mosaicism revealed by single cell sequencing
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010310
Abstract: Chromosomal mosaicism is common throughout human pre- and post-implantation development. However, the incidence and characteristics of mosaicism in human blastocyst remain unclear. Concerns and confusions still exist regarding the interpretation of chromosomal mosaicism on preimplantation… read more here.
Keywords: cell; human embryo; development; cell sequencing ... See more keywords
Genome Editing of Human Embryo: Allow or Prohibit?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Advanced Research in Law and Economics"
DOI: 10.14505/jarle.v11.2(48).21
Abstract: Nowadays, the direction of both law-enforcement activity and dynamically developing statutory regulation is to involve genes and genetic constructions into civil-law transactions. However, the evaluation of such processes is complex within the scope of doctrine… read more here.
Keywords: genome editing; law; prohibit genome; human embryo ... See more keywords
National human embryo and embryoid research policies: a survey of 22 top research-intensive countries.
Sign Up to like & getrecommendations! Published in 2020 at "Regenerative medicine"
DOI: 10.2217/rme-2019-0138
Abstract: Research using human embryos and embryoids has expanded in recent years due to technological advances. Surveying laws and guidelines among the top research and development (R&D) investing nations highlights existing barriers to expanding this area… read more here.
Keywords: research; embryoid research; laws guidelines; human embryo ... See more keywords
Metabolic Signature of Energy Metabolism Alterations and Excess Nitric Oxide Production in Culture Media Correlate with Low Human Embryo Quality and Unsuccessful Pregnancy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010890
Abstract: Notwithstanding the great improvement of ART, the overall rate of successful pregnancies from implanted human embryos is definitely low. The current routine embryo quality assessment is performed only through morphological criteria, which has poor predictive… read more here.
Keywords: culture; human embryo; embryo quality; pregnancy ... See more keywords
Human embryo polarization requires PLC signaling to mediate trophectoderm specification
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.65068
Abstract: Apico-basal polarization of cells within the embryo is critical for the segregation of distinct lineages during mammalian development. Polarized cells become the trophectoderm (TE), which forms the placenta, and apolar cells become the inner cell… read more here.
Keywords: embryo polarization; plc signaling; polarization; human embryo ... See more keywords