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   Articles with "human endogenous" as a keyword



Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic

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recommendations! Published in 2022 at "Annals of Neurology"

DOI: 10.1002/ana.26452

Abstract: Human endogenous retroviruses have been implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous retrovirus K (HERV‐K) subtype HML‐2 envelope (Env) in human neuronal cultures and in transgenic mice results in… read more here.

Keywords: lateral sclerosis; endogenous retrovirus; human endogenous; amyotrophic lateral ... See more keywords

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28350

Abstract: Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have… read more here.

Keywords: oncogenesis mechanisms; human endogenous; retroviruses cancer; cancer oncogenesis ... See more keywords

A New Insight on Activation of Human Endogenous Retroviruses (HERVs) in Malignant Melanoma upon Exposure to CuSO4

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recommendations! Published in 2018 at "Biological Trace Element Research"

DOI: 10.1007/s12011-018-1605-6

Abstract: Human endogenous retroviruses (HERVs) are semi-conserved subtypes of long-terminal repeats containing retrotransposons that constitute approximately 8% of the genome. Under pathological conditions, the expression of HERVs is also affected by epigenetic modifications. The extent to… read more here.

Keywords: melanoma; herv; exposure; copper ... See more keywords

Monitoring the Transcriptional Activity of Human Endogenous Retroviral HERV-W Family Using PNA Strand Invasion into Double-Stranded DNA

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recommendations! Published in 2018 at "Molecular Biotechnology"

DOI: 10.1007/s12033-017-0057-0

Abstract: In the presented assay, we elaborated a method for distinguishing sequences that are genetically closely related to each other. This is particularly important in a situation where a fine balance of the allele abundance is… read more here.

Keywords: strand invasion; human endogenous; pna strand; herv family ... See more keywords

A model of human endogenous retrovirus (HERV) activation in mental health and illness.

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recommendations! Published in 2019 at "Medical hypotheses"

DOI: 10.1016/j.mehy.2019.109404

Abstract: Despite strong evidence for the heritability of major depressive disorder (MDD), efforts to identify causal genes have been disappointing. Furthermore, although there is strong support for life stress as a major predictor of MDD, there… read more here.

Keywords: human endogenous; brain; herv activation; individual differences ... See more keywords
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Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest.

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recommendations! Published in 2020 at "Multiple sclerosis and related disorders"

DOI: 10.1016/j.msard.2020.102068

Abstract: The Third International Workshop on Human Endogenous Retroviruses and disease (www.hervanddisease.com), addressing HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer, in Lyon, France on November 5-6th 2019, once again gathered… read more here.

Keywords: autoimmune chronic; elements autoimmune; human endogenous; endogenous retroviruses ... See more keywords

Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-22734-7

Abstract: Human endogenous retrovirus (HERV) sequences make up at least 8% of the human genome. Transcripts originating from these loci as well as proteins encoded by them have been detected in various tissues. HERVs are believed… read more here.

Keywords: psoriatic skin; hervs repetitive; transcriptional landscape; repetitive elements ... See more keywords

Human Endogenous Retroviruses and Toll-Like Receptors.

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recommendations! Published in 2022 at "Viral immunology"

DOI: 10.1089/vim.2022.0090

Abstract: Human endogenous retroviruses (HERVs) are estimated to comprise ∼8% of the entire human genome, but the vast majority of them remain transcriptionally silent in most normal tissues due to accumulated mutations. However, HERVs can be… read more here.

Keywords: toll like; human endogenous; retroviruses toll; like receptors ... See more keywords
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The role of human endogenous retroviruses in gliomas: from etiological perspectives and therapeutic implications.

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recommendations! Published in 2021 at "Neuro-oncology"

DOI: 10.1093/neuonc/noab142

Abstract: Accounting for approximately 8% of the human genome, Human Endogenous Retroviruses (HERVs) have been implicated in a variety of cancers including gliomas. In normal cells, tight epigenetic regulation of HERVs prevent aberrant expression; however, in… read more here.

Keywords: hervs; human endogenous; endogenous retroviruses; anti tumor ... See more keywords

EPCO-13. HUMAN ENDOGENOUS RETROVIRUS (HERV) PLAYS A CRITICAL ROLE IN ONCOGENIC MECHANISM INIDH1-WILD TYPE GLIOBLASTOMAS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae165.0013

Abstract: IDH1-wildtype (WT) GBMs are the most common and aggressive tumors of the central nervous system (CNS), with a median survival rate of 12-15 months, and are resistant to clinical therapies due to their heterogenous molecular… read more here.

Keywords: human endogenous; oncogenic mechanism; epco human; role ... See more keywords

CNSC-56. HUMAN ENDOGENOUS RETROVIRUS K ENV ACTIVATES CD98HC/EGFR SIGNALING TO PROMOTE GLIOBLASTOMA PROGRESSION

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0264

Abstract: Human endogenous retrovirus-K (HERV-K), particularly the HML-2 subtype, is the most recently integrated human provirus and remains transcriptionally active in several cancers, including glioblastoma (GBM). Although its function in GBM has been poorly defined, we… read more here.

Keywords: egfr; human endogenous; herv env; gbm ... See more keywords