Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26452
Abstract: Human endogenous retroviruses have been implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous retrovirus K (HERV‐K) subtype HML‐2 envelope (Env) in human neuronal cultures and in transgenic mice results in… read more here.
Keywords: lateral sclerosis; endogenous retrovirus; human endogenous; amyotrophic lateral ... See more keywords
Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications
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DOI: 10.1002/jmv.28350
Abstract: Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have… read more here.
Keywords: oncogenesis mechanisms; human endogenous; retroviruses cancer; cancer oncogenesis ... See more keywords
A New Insight on Activation of Human Endogenous Retroviruses (HERVs) in Malignant Melanoma upon Exposure to CuSO4
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1605-6
Abstract: Human endogenous retroviruses (HERVs) are semi-conserved subtypes of long-terminal repeats containing retrotransposons that constitute approximately 8% of the genome. Under pathological conditions, the expression of HERVs is also affected by epigenetic modifications. The extent to… read more here.
Keywords: melanoma; herv; exposure; copper ... See more keywords
Monitoring the Transcriptional Activity of Human Endogenous Retroviral HERV-W Family Using PNA Strand Invasion into Double-Stranded DNA
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DOI: 10.1007/s12033-017-0057-0
Abstract: In the presented assay, we elaborated a method for distinguishing sequences that are genetically closely related to each other. This is particularly important in a situation where a fine balance of the allele abundance is… read more here.
Keywords: strand invasion; human endogenous; pna strand; herv family ... See more keywords
A model of human endogenous retrovirus (HERV) activation in mental health and illness.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109404
Abstract: Despite strong evidence for the heritability of major depressive disorder (MDD), efforts to identify causal genes have been disappointing. Furthermore, although there is strong support for life stress as a major predictor of MDD, there… read more here.
Keywords: human endogenous; brain; herv activation; individual differences ... See more keywords
Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102068
Abstract: The Third International Workshop on Human Endogenous Retroviruses and disease (www.hervanddisease.com), addressing HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer, in Lyon, France on November 5-6th 2019, once again gathered… read more here.
Keywords: autoimmune chronic; elements autoimmune; human endogenous; endogenous retroviruses ... See more keywords
Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin
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DOI: 10.1038/s41598-018-22734-7
Abstract: Human endogenous retrovirus (HERV) sequences make up at least 8% of the human genome. Transcripts originating from these loci as well as proteins encoded by them have been detected in various tissues. HERVs are believed… read more here.
Keywords: psoriatic skin; hervs repetitive; transcriptional landscape; repetitive elements ... See more keywords
Human Endogenous Retroviruses and Toll-Like Receptors.
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DOI: 10.1089/vim.2022.0090
Abstract: Human endogenous retroviruses (HERVs) are estimated to comprise ∼8% of the entire human genome, but the vast majority of them remain transcriptionally silent in most normal tissues due to accumulated mutations. However, HERVs can be… read more here.
Keywords: toll like; human endogenous; retroviruses toll; like receptors ... See more keywords
The role of human endogenous retroviruses in gliomas: from etiological perspectives and therapeutic implications.
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DOI: 10.1093/neuonc/noab142
Abstract: Accounting for approximately 8% of the human genome, Human Endogenous Retroviruses (HERVs) have been implicated in a variety of cancers including gliomas. In normal cells, tight epigenetic regulation of HERVs prevent aberrant expression; however, in… read more here.
Keywords: hervs; human endogenous; endogenous retroviruses; anti tumor ... See more keywords
A safety and pharmacodynamics study of temelimab, an antipathogenic human endogenous retrovirus type W envelope monoclonal antibody, in patients with type 1 diabetes
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DOI: 10.1111/dom.14010
Abstract: To report the first study of temelimab, a monoclonal antibody neutralizing the pathogenic human endogenous retrovirus type W envelope, in patients with type 1 diabetes (T1D). read more here.
Keywords: type envelope; study temelimab; human endogenous; retrovirus type ... See more keywords
p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00485-22
Abstract: Human endogenous retroviruses (HERVs) were integrated into the human genome in ancient times and have been coevolving with the host. Since the Human Genome Project, HERVs have attracted increasing attention. ABSTRACT The long terminal repeats… read more here.
Keywords: human endogenous; transcriptional activity; hml; activity ... See more keywords