Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27975
Abstract: Human enterovirus A71 (EV‐A71) is the major causative agent of hand‐foot‐and‐mouth disease (HFMD) commonly associated with severe neurological diseases, particularly in children under 5 years of age. Several investigational therapeutic agents and vaccine candidates are… read more here.
Keywords: human enterovirus; rock1; enterovirus a71; host ... See more keywords
A flavonoid compound library screen revealed potent antiviral activity of plant‐derived flavonoids on human enterovirus A71 replication
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.12.003
Abstract: Abstract Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71… read more here.
Keywords: antiviral activity; compound; human enterovirus; heva71 ... See more keywords
Immunoreactivity Analysis of the Nonstructural Proteins of Human Enterovirus 71.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2016.0110
Abstract: Human enterovirus 71 (EV-A71) is one of the main etiological agents of hand, foot, and mouth disease (HFMD), which has been prevalent mainly in the Asia-Pacific region in the past several decades. The nonstructural proteins… read more here.
Keywords: nonstructural proteins; proteins a71; immunoreactivity analysis; infection ... See more keywords
Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020115
Abstract: Hand-foot-and-mouth disease (HFMD) caused by human enterovirus A71 (EV-A71) infection has been associated with severe neurological complications. With the lack of an internationally approved antiviral, coupled with a surge in outbreaks globally, EV-A71 has emerged… read more here.
Keywords: novel andrographolide; enterovirus a71; discovery novel; andrographolide derivatives ... See more keywords
Human Enterovirus B: Selective Inhibition by Quinoxaline Derivatives and Bioinformatic RNA-Motif Identification as New Targets
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DOI: 10.3390/ph15020181
Abstract: The Enterovirus genus includes many viruses that are pathogenic in humans, including Coxsackie viruses and rhinoviruses, as well as the emerging enteroviruses D68 and A71. Currently, effective antiviral agents are not available for the treatment… read more here.
Keywords: human enterovirus; quinoxaline derivatives; new targets; enterovirus genus ... See more keywords