Comprehensive characterization and simultaneous analysis of overall lipids in reconstructed human epidermis using NPLC/HR-MSn: 1-O-E (EO) Cer, a new ceramide subclass
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02301-3
Abstract: Stratum corneum lipids are responsible for the skin’s barrier function. They are the final product of epidermis lipid biosynthesis. During this process, lipids evolve from simple to complex structures in three main levels respectively (stratum… read more here.
Keywords: nplc msn; human epidermis; comprehensive characterization; epidermis ... See more keywords
Immortalized equivalent human epidermis as a platform to evaluation hair dyes toxicity: Efficiency comparison between 3D and monolayer culture.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109227
Abstract: The use of 3D models in various scientific applications is becoming more popular to replace traditional monolayers models. In this work, we used a three-dimensional in-house model of epidermis using HaCaT immortalized cells to evaluate… read more here.
Keywords: monolayer; hair; toxicity; model ... See more keywords
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.02.010
Abstract: Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degeneration. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger… read more here.
Keywords: degeneration; synuclein; degeneration reconstructed; oligomeric synuclein ... See more keywords
Modeling dermatophytosis in reconstructed human epidermis: A new tool to study infection mechanisms and to test antifungal agents
Sign Up to like & getrecommendations! Published in 2017 at "Medical Mycology"
DOI: 10.1093/mmy/myw111
Abstract: &NA; Dermatophytosis is a superficial fungal infection of keratinized structures that exhibits an increasing prevalence in humans and is thus requesting novel prophylactic strategies and therapies. However, precise mechanisms used by dermatophytes to adhere at… read more here.
Keywords: modeling dermatophytosis; fungal infection; infection; human epidermis ... See more keywords
Particulate matter 2.5 induced hyperpigmentation in reconstructed human epidermis model (MelaKutis®)
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001934
Abstract: To the Editor: Epidemiological studies have confirmed Biocell Biotechnology), and NHEMs in Medium 254 that fine particulate matter (PM2.5) is related to skin hyperpigmentation, but experimental evidence is lacking. Here, we used normal human epidermal… read more here.
Keywords: reconstructed human; particulate matter; human epidermis; hyperpigmentation ... See more keywords
Reproducing the scalp microbiota community: co‐colonization of a 3D reconstructed human epidermis with C. acnes and M. restricta
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cosmetic Science"
DOI: 10.1111/ics.12688
Abstract: A 3D reconstructed human epidermis (RHE) model colonized with specific microbial strains was developed to model the complex interactions between strains of the human scalp hair. read more here.
Keywords: reproducing scalp; microbiota community; human epidermis; scalp microbiota ... See more keywords
Probing the human epidermis by combining ToF-SIMS and multivariate analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Biointerphases"
DOI: 10.1116/6.0002289
Abstract: The mammalian organism is continuously exposed to various biological and chemical threats from its surroundings. In order to provide protection against these threats, mammals have developed a specialized defense system at the interface with their… read more here.
Keywords: tof; methodology; tof sims; human epidermis ... See more keywords
Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02273-21
Abstract: Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is frequently associated with inflammatory skin disorders such as atopic dermatitis, where it aggravates symptoms. ABSTRACT Staphylococcus aureus causes a broad spectrum… read more here.
Keywords: human epidermis; reconstituted human; model; staphylococcus aureus ... See more keywords
Modeling of ultraviolet propagation from air to human epidermis with wavelength range of 200-300 nm.
Sign Up to like & getrecommendations! Published in 2022 at "Optics letters"
DOI: 10.1364/ol.452443
Abstract: Ultraviolet (UV) technology plays an important role in the fields of sterilization, disinfection, and short-range wireless optical communications. In this Letter, a theoretical model to determine the UV radiation intensity (UVRI) on human skin is… read more here.
Keywords: wavelength; human epidermis; range; 200 300 ... See more keywords
Improved Tool for Predicting Skin Irritation on Reconstructed Human Epidermis Models Based on Electrochemical Impedance Spectroscopy
Sign Up to like & getrecommendations! Published in 2023 at "Biosensors"
DOI: 10.3390/bios13020162
Abstract: The rabbit skin irritation test has been the standard for evaluating the irritation potential of chemicals; however, alternative methods that do not use animal testing are actively encouraged. Reconstructed human epidermis (RhE) models mimic the… read more here.
Keywords: spectroscopy; reconstructed human; electrochemical impedance; irritation ... See more keywords
Treatment with Docosahexaenoic Acid Improves Epidermal Keratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24173156
Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease that can cause skin barrier function damage. Although co-incubation with docosahexaenoic acid (DHA) exerts a positive effect on deficient skin models, no studies have investigated the… read more here.
Keywords: epidermal keratinocyte; docosahexaenoic acid; treatment; human epidermis ... See more keywords