Mercury chloride toxicity in human erythrocytes: enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-04062-5
Abstract: Mercury is among the most toxic heavy metals and a widespread environmental pollutant. Mercury chloride (HgCl2) is an inorganic compound of mercury which is easily absorbed in the gastrointestinal tract and then enters the blood… read more here.
Keywords: hemoglobin oxidation; mercury chloride; hgcl2; human erythrocytes ... See more keywords
Di-n-butyl phthalate, butylbenzyl phthalate and their metabolites induce haemolysis and eryptosis in human erythrocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.03.161
Abstract: Phthalates have been extensively used as plasticizers in various fields, including food, cosmetic, and pharmaceutical industry. Those compounds do not form covalent bonds to substances they are being added to, and thus they may migrate… read more here.
Keywords: phthalate; butyl phthalate; butylbenzyl phthalate; eryptosis ... See more keywords
In vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.10.009
Abstract: Two cytotoxic copper(II) complexes with N-H and N-methylated benzimidazole-derived ligands (Cu-L1 and Cu-L1Me; L1=bis(2-methylbenzimidazolyl)(2-methylthioethyl)amine, L1Me=bis(1-methyl-2-methylbenzimidazolyl)(2-methylthioethyl)amine) were synthesized and exposed to human erythrocytes and molecular models of its membrane. The latter were bilayers built-up of dimyristoylphosphatidylcholine… read more here.
Keywords: copper complexes; microscopy; vitro effects; l1me ... See more keywords
Dietary supplementation with annatto food-coloring extracts increases the resistance of human erythrocytes to hemolysis.
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition research"
DOI: 10.1016/j.nutres.2020.02.003
Abstract: Erythrocytes exhibit high susceptibility to hemolysis in several pathologies due to the oxidation of cellular components. We hypothesized that annatto carotenoids improve the redox status of erythrocyte plasma membranes and promote a consequent increase in… read more here.
Keywords: supplementation; hemolysis; food; resistance ... See more keywords
Thiram-induced cytotoxicity and oxidative stress in human erythrocytes: an in vitro study.
Sign Up to like & getrecommendations! Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.12.003
Abstract: Tetramethylthiuram disulfide, commonly known as thiram, is an organosulfur compound which is used as a bactericide, fungicide and ectoparasiticide to prevent disease in seeds and crops. Being a fungicide there is a high probability of… read more here.
Keywords: thiram; induced cytotoxicity; human erythrocytes; thiram induced ... See more keywords
Redox regulation of nitrosyl-hemoglobin in human erythrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101399
Abstract: Oxidative stress perturbs vascular homeostasis leading to endothelial dysfunction and cardiovascular diseases. Vascular reactive oxygen species (ROS) reduce nitric oxide (NO) bioactivity, a hallmark of cardiovascular and metabolic diseases. We measured steady-state vascular NO levels… read more here.
Keywords: state; hbno; redox regulation; steady state ... See more keywords
Proof of Concept: Protein Delivery into Human Erythrocytes Using Stable Cavitation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00907
Abstract: Human erythrocytes represent candidates of choice as carriers for a wide range of drugs due to their unique biophysical and physiological properties. In this study, we used a sonoporation device generating and monitoring acoustic stable… read more here.
Keywords: protein delivery; delivery human; human erythrocytes; cavitation ... See more keywords
Impact of drying processes on Bryophyllum pinnatum phenolic constituents and its anti-inflammatory and antioxidative activities in human erythrocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13298
Abstract: The effect of drying on the phytoconstituents, antioxidative, and anti-inflammatory properties of Bryophyllum pinnatum leaves was investigated. The phenolic constituents were characterized using HPLC-DAD. The aqueous extraction was done and various assays (Inhibition of membrane… read more here.
Keywords: anti inflammatory; bryophyllum pinnatum; phenolic constituents; freeze dried ... See more keywords
Comparative Analysis of the Effects of Olive Oil Hydroxytyrosol and Its 5-S-Lipoyl Conjugate in Protecting Human Erythrocytes from Mercury Toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/9042192
Abstract: Oxidative stress is one of the underlying mechanisms of the toxic effects exerted by mercury (Hg) on human health. Several antioxidant compounds, including the olive oil phenol hydroxytyrosol (HT), were investigated for their protective action.… read more here.
Keywords: comparative analysis; hydroxytyrosol; toxicity; human erythrocytes ... See more keywords
Piperine protects oxidative modifications in human erythrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2020-0100
Abstract: Abstract Objectives Piperine (1-piperoyl piperidine), a major alkaloid constituent of Piper nigrum L. and Piper longum L. has pleiotropic biological effects, but the mechanism(s) involved remain to be elucidated. The current study was conducted to… read more here.
Keywords: protects oxidative; modifications human; erythrocytes piperine; oxidative modifications ... See more keywords
Evaluating hemolytic and photo hemolytic potential of organophosphorus by in vitro method as an alternative tool using Human erythrocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200226104029
Abstract: The aim of the present study is to determine the phototoxic and haemolytic activity of organophosphorus. The use of alternative in vitro assays with human erythrocytes, are suggested to predict the polluting effect of these… read more here.
Keywords: hemolytic photo; evaluating hemolytic; vitro; malathion methamidophos ... See more keywords