HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17559
Abstract: Among histone deacetylases, HDAC6 is unusual in its cytoplasmic localization. Its inhibition leads to hyperacetylation of non‐histone proteins, inhibiting cell cycle, proliferation and apoptosis. Ricolinostat (ACY‐1215) is a selective inhibitor of the histone deacetylase HDAC6… read more here.
Keywords: erythroid differentiation; human erythroid; hdac6; acy 1215 ... See more keywords
The N-Terminal 5-68 Amino Acids Domain of the Minor Capsid Protein VP1 of Human Parvovirus B19 Enters Human Erythroid Progenitors and Inhibits B19 Infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00466-21
Abstract: Human parvovirus B19 infection causes severe hematological disorders, including transient aplastic crisis, pure red cell aplasia, and hydrops fetalis. A productive B19 infection is highly restricted to human erythroid progenitors in human bone marrow and… read more here.
Keywords: human erythroid; infection; erythroid progenitors; b19 infection ... See more keywords
LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117675
Abstract: Significant amount of clinical literatures have supported that high level of fetal hemoglobin (HbF) improves the disease pathophysiology of β-globinopathies [sickle cell disease (SCD) and β-thalassemia]. Thus, we certainly can treat β-globinopathies by increasing the… read more here.
Keywords: human erythroid; gsk lsd1; fetal hemoglobin; lsd1 ... See more keywords