ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Acta pharmacologica Sinica"
DOI: 10.1038/aps.2017.78
Abstract: Both the anti- and pro-apoptotic members of the Bcl-2 family are regulated by a conserved Bcl-2 homology (BH3) domain. ABT-263 (Navitoclax), a novel BH3 mimetic and orally bioavailable Bcl-2 family inhibitor with high affinity for… read more here.
Keywords: esophageal cancer; abt 263; human esophageal; cancer cells ... See more keywords
Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis
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DOI: 10.1038/s41598-019-41147-8
Abstract: There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full… read more here.
Keywords: eosinophilic esophagitis; mucosa; esophageal mucosa; human esophageal ... See more keywords
Abstract 1868: Molecular imaging of human esophageal cancer for early detection
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1868
Abstract: Esophageal cancer was the sixth common cancer for incidence and ranks fourth for death rate in China, and squamous cell carcinoma is the main histological type. It is usually in an advanced stage at the… read more here.
Keywords: esophageal cancer; human esophageal; imaging human; cancer early ... See more keywords
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159093
Abstract: Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE), an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells at single-cell resolution during homeostasis and EoE. During allergic inflammation, the… read more here.
Keywords: esophageal epithelium; cell; inflammation; human esophageal ... See more keywords
Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0700-2
Abstract: BackgroundEmerging evidence has suggested that interleukin (IL)-33 and its primary functional receptor ST2 are involved in the pathogenesis of tumorigenesis.MethodsUsing immunohistochemistry (IHC) and double immunofluorescence staining, we characterized the cellular and clinicopathological features of the… read more here.
Keywords: cellular clinicopathological; st2 axis; features st2; human esophageal ... See more keywords
Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Acta medica Okayama"
DOI: 10.18926/amo/63425
Abstract: The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer.… read more here.
Keywords: cancer; esophageal cancer; human esophageal; obp 301 ... See more keywords
Sporamin suppresses growth of human esophageal squamous cell carcinoma cells by inhibition of NF‑κB via an AKT‑independent pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7772
Abstract: The aim of the present study was to determine whether sporamin, a trypsin inhibitor, suppresses the growth of human esophageal squamous cell carcinoma (ESCC) cells in vitro. Sporamin treatment led to the suppression of viability and… read more here.
Keywords: sporamin; human esophageal; cell; growth human ... See more keywords
Emodin inhibits proliferation and invasion, and induces apoptosis in human esophageal cancer cell line ECA109
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i4.6
Abstract: Purpose: To determine the anticancer effects of emodin in human esophageal carcinoma cell line ECA109. Methods: Cell viability was determined by MTT assay, while cell invasion and apoptosis were measured by Transwell assay and flow… read more here.
Keywords: esophageal cancer; cell; invasion; human esophageal ... See more keywords