Harnessing the potential of CRISPR-Cas9 to advance the study of human fungal pathogens
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2017.1375851
Abstract: ABSTRACT Introduction: CRISPR-Cas9 has emerged as an important new tool for genetic engineering. While much has been written about the potential of this technology to treat human disease, relatively little has attention has been paid… read more here.
Keywords: human fungal; study human; crispr; fungal pathogens ... See more keywords
Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen
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DOI: 10.1128/mbio.01876-22
Abstract: Over the past decade, Candida auris has emerged as a highly transmissible human fungal pathogen. Because of its ability to transmit between patients in hospitals and its ability to rapidly develop drug resistance, C. auris… read more here.
Keywords: fungal pathogen; human fungal; resistance; drug ... See more keywords
Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00508-21
Abstract: Candida parapsilosis is an emerging major human fungal pathogen, especially in neonates. Aneuploidy, having uneven numbers of chromosomes, is a well-known mechanism for adapting to stress in Candida albicans, the most common human fungal pathogen.… read more here.
Keywords: adaptation; human fungal; tolerance; candida parapsilosis ... See more keywords
Proteomic Analysis of Copper Toxicity in Human Fungal Pathogen Cryptococcus neoformans
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.662404
Abstract: Cryptococcus neoformans is an invasive human fungal pathogen that causes more than 181,000 deaths each year. Studies have demonstrated that pulmonary C. neoformans infection induces innate immune responses involving copper, and copper detoxification in C.… read more here.
Keywords: human fungal; fungal pathogen; cryptococcus neoformans; copper ... See more keywords
Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.588913
Abstract: Over the past few decades advances in modern medicine have resulted in a global increase in the prevalence of fungal infections. Particularly people undergoing organ transplants or cancer treatments with a compromised immune system are… read more here.
Keywords: human fungal; fk506 rapamycin; fungal pathogens; small molecules ... See more keywords
Morphology Changes in Human Fungal Pathogens upon Interaction with the Host
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fungi"
DOI: 10.3390/jof3040066
Abstract: Morphological changes are a very common and effective strategy for pathogens to survive in the mammalian host. During interactions with their host, human pathogenic fungi undergo an array of morphological changes that are tightly associated… read more here.
Keywords: human fungal; morphology changes; changes human; fungal pathogens ... See more keywords
ATAC-Seq Identifies Chromatin Landscapes Linked to the Regulation of Oxidative Stress in the Human Fungal Pathogen Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fungi"
DOI: 10.3390/jof6030182
Abstract: Human fungal pathogens often encounter fungicidal stress upon host invasion, but they can swiftly adapt by transcriptional reprogramming that enables pathogen survival. Fungal immune evasion is tightly connected to chromatin regulation. Hence, fungal chromatin modifiers… read more here.
Keywords: human fungal; atac seq; chromatin; stress ... See more keywords
Chaperone Networks in Fungal Pathogens of Humans
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DOI: 10.3390/jof7030209
Abstract: The heat shock proteins (HSPs) function as chaperones to facilitate proper folding and modification of proteins and are of particular importance when organisms are subjected to unfavourable conditions. The human fungal pathogens are subjected to… read more here.
Keywords: human fungal; fungal pathogens; chaperone networks; pathogens humans ... See more keywords
Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8101102
Abstract: Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug resistance reduces the efficacy of currently approved treatment options, highlighting an urgent need for… read more here.
Keywords: fungal pathogens; gpi anchor; mgx; human fungal ... See more keywords