Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.1042/bcj20200499
Abstract: Human galectin-7 (Gal-7; also termed p53-induced gene 1 product) is a multifunctional effector by productive pairing with distinct glycoconjugates and protein counter-receptors in the cytoplasm and nucleus, as well as on the cell surface. Its… read more here.
Keywords: state; human galectin; galectin; isomerization ... See more keywords
How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1.
Sign Up to like & getrecommendations! Published in 2019 at "Glycobiology"
DOI: 10.1093/glycob/cwz034
Abstract: Discoveries on involvement of glycan-protein recognition in many (patho)physiological processes are directing attention to exploring the significance of a fundamental structural aspect of sugar receptors beyond glycan specificity, i.e., occurrence of distinct types of modular… read more here.
Keywords: galectin; human galectin; modular architecture; activity ... See more keywords
Saturation Transfer Difference NMR and Molecular Docking Interaction Study of Aralkyl-Thiodigalactosides as Potential Inhibitors of the Human-Galectin-3 Protein
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25031742
Abstract: Human Galectin-3 (hGal-3) is a protein that selectively binds to β-galactosides and holds diverse roles in both normal and pathological circumstances. Therefore, targeting hGal-3 has become a vibrant area of research in the pharmaceutical chemistry.… read more here.
Keywords: molecular docking; saturation transfer; human galectin; transfer difference ... See more keywords
Cysteine Oxidation in Human Galectin-1 Occurs Sequentially via a Folded Intermediate to a Fully Oxidized Unfolded Form
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DOI: 10.3390/ijms25136956
Abstract: Galectins are multifunctional effectors in cellular homeostasis and dysregulation. Oxidation of human galectin-1 (Gal-1) with its six sulfhydryls produces a disulfide-bridged oxidized form that lacks normal lectin activity yet gains new glycan-independent functionality. Nevertheless, the… read more here.
Keywords: human galectin; fully oxidized; oxidation human; oxidation ... See more keywords
Binding of Gold(III) Porphyrin by the Pro-metastatic Regulatory Protein Human Galectin-3
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DOI: 10.3390/molecules24244561
Abstract: Gold(III) porphyrin presents an attractive alternative to the use of, for example, cisplatin in chemotherapy. However, approaches that allow to selectively target cancer cells are highly sought. Many plant and mammalian lectins have been shown… read more here.
Keywords: gold iii; galectin; human galectin; iii porphyrin ... See more keywords