Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP
Sign Up to like & getrecommendations! Published in 2024 at "Blood Advances"
DOI: 10.1182/bloodadvances.2023012155
Abstract: Key Points • Human FcγRIII monovalent blocking as a 1-armed antibody or albumin fusion protein are effective in a humanized model of ITP.• The monovalent albumin fusion protein showed no AEs, whereas the Fc-impaired 1-armed… read more here.
Keywords: model itp; receptor iiia; gamma receptor; human gamma ... See more keywords
The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
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DOI: 10.18632/oncotarget.17074
Abstract: The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both neurotoxic.… read more here.
Keywords: aggregation; antigen binding; human gamma; sheet ... See more keywords