Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma
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DOI: 10.1002/1878-0261.12320
Abstract: TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of… read more here.
Keywords: glioblastoma; loss function; tumorigenicity; human gbm ... See more keywords
5alpha-dihydroprogesterone promotes proliferation and migration of human glioblastoma cells
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DOI: 10.1016/j.steroids.2020.108708
Abstract: Glioblastomas (GBMs) are the most common and deadliest intracranial tumors. Steroid hormones, such as progesterone (P4), at physiological concentrations, promote proliferation, and migration of human GBM cells in vivo and in vitro. Neuronal and glial… read more here.
Keywords: proliferation migration; human gbm; migration; migration human ... See more keywords
TMOD-20. A SWINE MODEL OF GLIOBLASTOMA INDUCED BY SOMATIC GENE MODIFICATION
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.971
Abstract: Glioblastoma (GBM) is the most common and malignant primary brain tumor. Novel therapeutic development for GBM is needed since the standard of care universally fails to cure patients and the five-year survival rate remains below… read more here.
Keywords: glioblastoma; gbm; gene modification; model ... See more keywords