Advances in the role of natural products in human gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Natural Medicines"
DOI: 10.1016/s1875-5364(22)60147-x
Abstract: Natural products (NPs), especially those from traditional herbal medicines, can evidently modulate human gene expression at multiple levels, leading to a wide diversity of bioactivities. However, although we have found numerous bio-functions of NPs for… read more here.
Keywords: natural products; role; human gene; gene ... See more keywords
Human gene essentiality
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Genetics"
DOI: 10.1038/nrg.2017.75
Abstract: A gene can be defined as essential when loss of its function compromises viability of the individual (for example, embryonic lethality) or results in profound loss of fitness. At the population level, identification of essential… read more here.
Keywords: gene essentiality; human gene; genetics; gene ... See more keywords
Regulatory feedback loops bridge the human gene regulatory network and regulate carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbx166
Abstract: The development of disease involves a systematic disturbance inside cells and is associated with changes in the interactions or regulations among genes forming biological networks. The bridges inside a network are critical in shortening the… read more here.
Keywords: interface core; regulatory network; network; human gene ... See more keywords
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Sign Up to like & getrecommendations! Published in 2023 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evad081
Abstract: Abstract T cells are a type of white blood cell that play a critical role in the immune response against foreign pathogens through a process called T cell adaptive immunity (TCAI). However, the evolution of… read more here.
Keywords: gene age; adaptive immune; immune; gene ... See more keywords
KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz881
Abstract: Abstract Transcription factors (TFs) and their target genes have important functions in human diseases and biological processes. Gene expression profile analysis before and after knockdown or knockout is one of the most important strategies for… read more here.
Keywords: expression profile; knockdown knockout; human gene; gene expression ... See more keywords
Vulnerable groups and the hollow promise of benefit from human gene editing.
Sign Up to like & getrecommendations! Published in 2021 at "Bioethics"
DOI: 10.1111/bioe.12882
Abstract: Mainstream academic debate on the ethics of human gene editing is currently not as inclusive as it should be. For example, it currently does not give due consideration to Indigenous groups and cultures, such as… read more here.
Keywords: gene editing; human gene; vulnerable groups; groups hollow ... See more keywords
Global Governance of Human Genome Editing: What Are the Rules?
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-111320-091930
Abstract: Human gene editing, particularly using the new CRISPR/Cas9 technology, will greatly increase the capability to make precise changes to human genomes. Human gene editing can be broken into four major categories: somatic therapy, heritable gene… read more here.
Keywords: gene editing; human gene; genetics; global governance ... See more keywords
Clinical Value Screening, Prognostic Significance, and Key Gene Identification of TrkB in Laryngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1354005
Abstract: Purpose Using human gene chip expression profiling technology to screen out downstream genes related to TrkB regulation in laryngeal cancer cells. Methods Using the Hep-2 TrkB shRNA cell line, divide it into an experimental group… read more here.
Keywords: cell; human gene; differential genes; analysis ... See more keywords
The impact of whole genome duplications on the human gene regulatory networks
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009638
Abstract: This work studies the effects of the two rounds of Whole Genome Duplication (WGD) at the origin of the vertebrate lineage on the architecture of the human gene regulatory networks. We integrate information on transcriptional… read more here.
Keywords: regulatory networks; gene regulatory; duplications human; human gene ... See more keywords
Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0219276
Abstract: PCR inhibition is frequent in medical microbiology routine practice and may lead to false-negative results; however there is no consensus on how to detect it. Pathogen-specific and human gene amplifications are widely used to detect… read more here.
Keywords: pcr; human gene; pathogen specific; inhibition ... See more keywords
β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells
Sign Up to like & getrecommendations! Published in 2018 at "Life Science Alliance"
DOI: 10.26508/lsa.201800059
Abstract: This study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell. Microtubules are highly dynamic… read more here.
Keywords: terminal tails; microtubule dynamics; human gene;