In silico prediction of human genes as potential targets for rice miRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2020.107305
Abstract: BACKGROUND Exogenous microRNAs (miRNAs) enter the human body through food, and their effects on metabolic processes can be considerable. It is important to determine which miRNAs from plants affect the expression of human genes and… read more here.
Keywords: osa; human genes; binding sites; mrnas human ... See more keywords
Biomedicine: Human genes lost and their functions found
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/544171a
Abstract: Individuals who lack a functional copy of a gene — gene knockouts — can reveal the gene's role. Most knockout research has used model organisms, but now a comprehensive catalogue of human knockouts is in… read more here.
Keywords: function mutations; loss function; biomedicine human; human genes ... See more keywords
Daily briefing: Why potentially useful human genes are being ignored by science
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-06775-6
Abstract: Why genetics research still focuses on the same old genes, a whole new level of quantum weirdness and lessons from a huge science scandal. Why genetics research still focuses on the same old genes, a… read more here.
Keywords: potentially useful; briefing potentially; genetics; useful human ... See more keywords
Using deep learning to associate human genes with age-related diseases
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz887
Abstract: Abstract Motivation One way to identify genes possibly associated with ageing is to build a classification model (from the machine learning field) capable of classifying genes as associated with multiple age-related diseases. To build this… read more here.
Keywords: age related; related diseases; method; model ... See more keywords
Reconstruction of human genome evolution in yeast: an educational primer for use with “systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes”
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab118
Abstract: The evolution of eukaryotic organisms starting with the last eukaryotic common ancestor was accompanied by lineage-specific expansion of gene families. A paper by Garge et al. provides an excellent opportunity to have students explore how… read more here.
Keywords: evolution; systematic humanization; human genes; reconstruction human ... See more keywords
Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx020
Abstract: Abstract Genomic DNA methylation maps (methylomes) encode genetic and environmental effects as stable chemical modifications of DNA. Variations in DNA methylation, especially in regulatory regions such as promoters and enhancers, are known to affect numerous… read more here.
Keywords: prone cancer; human genes; cancer; cancer associated ... See more keywords
The characteristics of early-stage research into human genes are substantially different from subsequent research
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001520
Abstract: Throughout the last 2 decades, several scholars observed that present day research into human genes rarely turns toward genes that had not already been extensively investigated in the past. Guided by hypotheses derived from studies… read more here.
Keywords: early stage; stage research; human genes; research human ... See more keywords
Pathogenic variation types in human genes relate to diseases through Pfam and InterPro mapping
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.966927
Abstract: Grouping residue variations in a protein according to their physicochemical properties allows a dimensionality reduction of all the possible substitutions in a variant with respect to the wild type. Here, by using a large dataset… read more here.
Keywords: pfam interpro; types human; human genes; variation ... See more keywords