Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.
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DOI: 10.1021/acs.jmedchem.1c01913
Abstract: Novel analogues of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and… read more here.
Keywords: inhibitors human; geranylgeranyl pyrophosphate; thienopyrimidine based; pyrophosphate synthase ... See more keywords