Germ-Inating Solutions or Gene-Rating Problems: An Islamic Perspective on Human Germline Gene Editing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Religion and Health"
DOI: 10.1007/s10943-019-00770-5
Abstract: Human germline gene editing (hGGE) poses many questions for the Muslim community. They range from the scientific: is there sufficient evidence that hGGE is better than existing technologies? To the ethical: is the lack of… read more here.
Keywords: gene editing; germ inating; human germline; gene ... See more keywords
Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion
Sign Up to like & getrecommendations! Published in 2020 at "Science and Engineering Ethics"
DOI: 10.1007/s11948-019-00098-z
Abstract: The recent development of CRISPR/Cas9 technology has rekindled the ethical debate concerning human germline modification that has begun decades ago. This inexpensive technology shows tremendous promise in disease prevention strategies, while raising complex ethical concerns… read more here.
Keywords: gene editing; crispr cas9; human germline; germline ... See more keywords
Human germline genome editing is illegal in Canada, but could it be desirable for some members of the rare disease community?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Community Genetics"
DOI: 10.1007/s12687-019-00430-x
Abstract: Human germline genome editing may prove to be especially poignant for members of the rare disease community, many of whom are diagnosed with monogenic diseases. This community lacks broad representation in the literature surrounding genome… read more here.
Keywords: genome editing; germline genome; community; rare disease ... See more keywords
Human germline editing: Insights to future clinical treatment of diseases
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DOI: 10.1007/s13238-018-0594-8
Abstract: 1 Key Laboratory for Major Obstetric Diseases of Guangdong Province, Center of Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China 2 Disease Modeling and Therapeutics Laboratory, A*STAR Institute of Molecular… read more here.
Keywords: insights future; medicine; editing insights; future clinical ... See more keywords
Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
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DOI: 10.1038/s41598-021-00669-w
Abstract: The design of superior biologic therapeutics, including antibodies and engineered proteins, involves optimizing their specific ability to bind to disease-related molecular targets. Previously, we developed and applied the Assisted Design of Antibody and Protein Therapeutics… read more here.
Keywords: antibody; derived sequences; human germline; redesigning antibody ... See more keywords
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210517
Abstract: Programmed cell death has long been characterised as a key player in the development of human disease. Necroptosis is a lytic form of programmed cell death that is universally mediated by the effector protein mixed… read more here.
Keywords: necroptosis; human germline; germline gene; gene variants ... See more keywords
CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’*
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsz010
Abstract: Abstract The world was shocked in Nov. 25, 2018 by the revelation that He Jiankui had used clustered regularly interspaced short palindromic repeats (‘CRISPR’) to edit embryos—two of which had, sometime in October, become living… read more here.
Keywords: germline genome; genome editing; jiankui affair; human germline ... See more keywords
Origin and segregation of the human germline
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DOI: 10.1101/2022.07.06.498671
Abstract: Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. While direct studies are hindered, here we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro models with temporally resolved single-cell… read more here.
Keywords: cell; human germline; germline; segregation human ... See more keywords
Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medical Ethics"
DOI: 10.1186/s12910-020-00487-1
Abstract: Background Clustered Regularly Interspaced Short Palindromic Repeats-associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates… read more here.
Keywords: germline; crispr cas; human germline; germline editing ... See more keywords
Similarities between bovine and human germline development revealed by single-cell RNAseq.
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DOI: 10.1530/rep-20-0313
Abstract: The germ cell lineage ensures the creation of new individuals and perpetuates the genetic information across generations. Primordial germ cells are pioneers of gametes and exist transiently during development until they differentiate into oogonia in… read more here.
Keywords: primordial germ; bovine human; development; germ cells ... See more keywords