RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03010-0
Abstract: IntroductionWe sought to determine which therapeutically targetable immune checkpoints, costimulatory signals, and other tumor microenvironment (TME) factors are independently associated with immune cytolytic activity (CYT), a gene expression signature of activated effector T cells, in… read more here.
Keywords: cyt; therapeutically targetable; rna seq; expression ... See more keywords
Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02382-1
Abstract: A substantial literature supports the notion that cancer is a metabolic disease. Mitochondria are sexually dimorphic, and progesterone (P4) plays a key regulatory role in mitochondrial functions. We investigated the effect of P4 on mitochondrial… read more here.
Keywords: gbm; effect; rate; human glioblastoma ... See more keywords
Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line.
Sign Up to like & getrecommendations! Published in 2018 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2018.06.026
Abstract: In this study, antibody-conjugated biodegradable polymeric nanoparticles were developed to enhance the photodaynamic efficiency of curcumin (CUR) on glioblastoma tumor cells. Poly (D, l-lactic-co-glycolic acid) nanoparticles (PLGA NPs) were synthesized and stabilized by polyvinyl alcohol… read more here.
Keywords: photodynamic therapy; cell; plga nps; cur ... See more keywords
Investigation of Cytotoxicity and Oxidative Stress Induced by the Pyrethroid Bioallethrin in Human Glioblastoma Cells: The Protective Effect of Vitamin E (VE) and Its Underlying Mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00033
Abstract: Bioallethrin belongs to the family of pyrethroid insecticides. Previous studies have shown that bioallethrin affected the function of muscarinic receptor and subsequently induced neurotoxicity in different brain models. Reactive oxygen species (ROS) are generated in… read more here.
Keywords: glioblastoma cells; cytotoxicity; human glioblastoma; bioallethrin ... See more keywords
Intratumoral heterogeneity of endogenous tumor cell invasive behavior in human glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36280-9
Abstract: Intratumoral genetic heterogeneity is a widely accepted characteristic of human cancer, including the most common primary malignant brain tumor, glioblastoma. However, the variability in biological behaviors amongst cells within individual tumors is not well described.… read more here.
Keywords: behavior human; glioblastoma; tumor cell; human glioblastoma ... See more keywords
Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93663-1
Abstract: The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized… read more here.
Keywords: adaptation human; transcription factor; activating transcription; glioblastoma cells ... See more keywords
Application of the anthraquinone drug rhein as an axial ligand in bifunctional Pt(IV) complexes to obtain antiproliferative agents against human glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt00235c
Abstract: Octahedral Pt(IV) prodrugs are an effective way to combine cisplatin-like moieties and a second drug to obtain selective and stimuli responsive bifunctional antiproliferative compounds. Recently, two bifunctional Pt(IV) complexes have shown interesting in vitro and… read more here.
Keywords: bifunctional complexes; human glioblastoma; cisplatin; drug ... See more keywords
Aminobenzofuran-containing analogues of proximicins exhibit higher antiproliferative activity against human UG-87 glioblastoma cells compared to temozolomide
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00107e
Abstract: A new series of proximicin analogues containing a benzofuran moiety as the replacement of the di-furan scaffold of the parent compound were synthesised and evaluated for their anti-proliferative activities against human glioblastoma cells U-87 MG.… read more here.
Keywords: glioblastoma cells; higher antiproliferative; glioblastoma; human glioblastoma ... See more keywords
Detailed in vitro analyses of the impact of multimodal cancer therapy with hyperthermia and radiotherapy on the immune phenotype of human glioblastoma cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2022.2080873
Abstract: Abstract Purpose Improvements of heat-delivery systems have led to hyperthermia (HT) being increasingly recognized as an adjunct treatment modality also for brain tumors. But how HT affects the immune phenotype of glioblastoma cells is only… read more here.
Keywords: glioblastoma cells; hyperthermia; glioblastoma; human glioblastoma ... See more keywords
Impact of extremely low-frequency electromagnetic field (100 Hz, 100 G) exposure on human glioblastoma U87 cells during Temozolomide administration
Sign Up to like & getrecommendations! Published in 2019 at "Electromagnetic Biology and Medicine"
DOI: 10.1080/15368378.2019.1625784
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is a highly malignant brain tumor with an extremely dismal prognosis, a median survival is12 months. Temozolomide (TMZ) is an alkylating agent widely used to treat cancer, resistance to this drug… read more here.
Keywords: 100 100; u87 cells; glioblastoma; glioblastoma u87 ... See more keywords
Phenethyl Isothiocyanate Suppresses the Proinflammatory Cytokines in Human Glioblastoma Cells through the PI3K/Akt/NF-κB Signaling Pathway In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2108289
Abstract: Phenethyl isothiocyanate (PEITC), extracted from cruciferous vegetables, showed anticancer activity in many human cancer cells. Our previous studies disclosed the anticancer activity of PEITC in human glioblastoma multiforme (GBM) 8401 cells, including suppressing the cell… read more here.
Keywords: glioblastoma cells; cell; signaling pathway; human glioblastoma ... See more keywords