Structural Switching/ polymorphism by sequential base substitution at quasi-palindromic SNP site (G→A), in LCR of Human β-globin Gene cluster.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.12.142
Abstract: The human β-globin gene Locus Control Region (LCR), a dominant regulator of globin gene expression contains five tissue-specific DNase I-hypersensitive sites (HSs). A single nucleotide polymorphism (SNP) (A→G) present in HS4 region of locus control… read more here.
Keywords: globin gene; base; human globin; gene ... See more keywords
An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0217532
Abstract: Transcriptome analyses show a surprisingly large proportion of the mammalian genome is transcribed; much more than can be accounted for by genes and introns alone. Most of this transcription is non-coding in nature and arises… read more here.
Keywords: globin genes; adult; globin; non coding ... See more keywords