Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00327-1
Abstract: Nitric oxide (NO) plays a prominent physiological role as a low-molecular-mass signal molecule involved in diverse biological functions. Great attention has been directed to pharmacologically modulating the release of NO for various therapeutic applications. We… read more here.
Keywords: human glutathione; role human; glutathione transferases; role ... See more keywords
Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1
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DOI: 10.3390/antiox12010063
Abstract: The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the inhibition potency of two curcuminoids and eleven monocarbonyl curcumin analogues… read more here.
Keywords: curcumin analogues; monocarbonyl curcumin; glutathione transferase; curcumin ... See more keywords
The Interaction of the Flavonoid Fisetin with Human Glutathione Transferase A1-1
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DOI: 10.3390/metabo11030190
Abstract: Glutathione transferases (GSTs) are a family of Phase II detoxification enzymes that are involved in the development of the multidrug resistance (MDR) mechanism in cancer cells and therefore affect the clinical outcome of cancer chemotherapy.… read more here.
Keywords: fisetin human; human glutathione; fisetin; cancer ... See more keywords
The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes
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DOI: 10.3390/molecules26082399
Abstract: Human glutathione transferase A1-1 (hGSTA1-1) contributes to developing resistance to anticancer drugs and, therefore, is promising in terms of drug-design targets for coping with this phenomenon. In the present study, the interaction of anthraquinone and… read more here.
Keywords: glutathione transferase; interaction human; human glutathione; glutathione ... See more keywords