The Impact of Endogenous Breast Cancer Resistance Protein on Human P-Glycoprotein-Mediated Transport Assays Using LLC-PK1 Cells Transfected With Human P-Glycoprotein.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.012
Abstract: Lilly Laboratories cell porcine kidney 1 (LLC-PK1) cells transfected with human P-glycoprotein (LLC-PK1-P-gp) are widely used in transport assays to identify drug candidates that function as substrates of this efflux transporter. Endogenous transporters expressed in… read more here.
Keywords: pk1 cells; llc pk1; transport assays; human glycoprotein ... See more keywords
Exploring movement and energy in human P-glycoprotein conformational rearrangement
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1461133
Abstract: Human P-glycoprotein (P-gp), a kind of ATP-Binding Cassette transporter, can export a diverse variety of anti-cancer drugs out of the tumor cell. Its overexpression is one of the main reasons for the multidrug resistance (MDR)… read more here.
Keywords: energy; conformational rearrangement; exploring movement; rearrangement ... See more keywords
Immobilized fibrinogen activates human platelets through glycoprotein VI
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.182972
Abstract: Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen. Full… read more here.
Keywords: human platelets; fibrinogen; fibrinogen activates; platelets glycoprotein ... See more keywords
Study of Allosteric Transitions of Human P-Glycoprotein by Using the Two-State Anisotropic Network Model
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DOI: 10.3389/fmed.2022.815355
Abstract: Human P-glycoprotein (P-gp) is a kind of ATP-binding cassette (ABC) transporters. Once human P-gp is overexpressed in tumor cells, which can lead to tumor multidrug resistance (MDR). However, the present experimental methods are difficult to… read more here.
Keywords: state; network model; human glycoprotein; two state ... See more keywords