Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1979
Abstract: Gap junctional intercellular communication (GJIC) is the transfer of ions, metabolites, and second messengers between neighboring cells through intercellular junctions. Connexin 43 (Cx43) was found to be the type of gap junction protein responsible for… read more here.
Keywords: granulosa cells; communication; junctional intercellular; intercellular communication ... See more keywords
CDK4/6 inhibitor protects chemerin‐induced human granulosa‐lutein cells from apoptosis by inhibiting the p53/p21 waf pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23241
Abstract: Dysregulation of the cell cycle is common in human tumorigenesis. Therefore, CDK4/6 inhibitors targeting the cell cycle have been developed, and their antiapoptotic effects have been highly correlated with potential clinical therapies. The aim of… read more here.
Keywords: cdk4 inhibitor; hgl cells; chemerin induced; granulosa lutein ... See more keywords
SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.05.017
Abstract: Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) is a transforming growth factor β (TGF-β) type I receptor antagonist that negatively regulates TGF-β and bone morphogenetic protein (BMP) signaling. BAMBI has been shown to be… read more here.
Keywords: bambi; morphogenetic protein; bone morphogenetic; human granulosa ... See more keywords
Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.08.016
Abstract: OBJECTIVE To study the biological effects of resveratrol on the growth, electrophysiology, and mitochondrial function of human granulosa cells (h-GCs). DESIGN Preclinical study. SETTING Electrophysiology laboratory and in vitro fertilization unit. PATIENT(S) This study included h-GCs… read more here.
Keywords: granulosa cells; resveratrol; mitochondrial biogenesis; granulosa ... See more keywords
ALK4-SMAD2/3-SMAD4 signaling mediates the activin A-induced suppression of PTX3 in human granulosa-lutein cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110485
Abstract: As one of the members of the transforming growth factor-β (TGF-β) superfamily, activin A plays an important role in regulating follicular development and oocyte maturation. Pentraxin 3 (PTX3) is the key component that promotes the… read more here.
Keywords: ptx3 human; smad4; ptx3; expression ... See more keywords
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c18734
Abstract: Tissue engineering advancements have made it possible to modify biomaterials to reconstruct a similar three-dimensional structure of the extracellular matrix (ECM) for follicle development and to supply the required biological signals. We postulated that an… read more here.
Keywords: culture; human granulosa; three dimensional; granulosa cells ... See more keywords
Activin A promotes hyaluronan production and upregulates versican expression in human granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac070
Abstract: Abstract Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and… read more here.
Keywords: human granulosa; activin; production; hyaluronan ... See more keywords
Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad026
Abstract: Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide–dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates nonhistone substrates, e.g., tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ . Consequently,… read more here.
Keywords: granulosa lutein; human granulosa; camp; granulosa ... See more keywords
Two waves of transcriptomic changes in periovulatory human granulosa cells.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa043
Abstract: STUDY QUESTION How does the human granulosa cell (GC) transcriptome change during ovulation? SUMMARY ANSWER Two transcriptional peaks were observed at 12 h and at 36 h after induction of ovulation, both dominated by genes and pathways… read more here.
Keywords: study; human granulosa; ovulation; factor ... See more keywords
ALK2/ALK3‐BMPR2/ACVR2A Mediate BMP2‐Induced Downregulation of Pentraxin 3 Expression in Human Granulosa‐Lutein Cells
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2017-00436
Abstract: &NA; Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor‐&bgr; superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined.… read more here.
Keywords: bmp2; expression; human granulosa; granulosa lutein ... See more keywords
SNAIL Mediates TGF-&bgr;1–Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03127
Abstract: Transforming growth factor-β (TGF-β) 1 plays a critical role in regulating follicular development, and its dysregulation has been shown to be involved in the pathogenesis of ovulation dysfunction. SNAIL is a well-known transcriptional repressor that… read more here.
Keywords: ptx3; mediates tgf; snail; expression ... See more keywords