Ligand-induced glutathione transferase degradation as a therapeutic modality: Investigation of a new metal-mediated affinity cleavage strategy for human GSTP1-1.
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DOI: 10.1016/j.ijbiomac.2018.04.187
Abstract: Glutathione transferases (GST, EC. 2.5.1.18) are overexpressed in cancer cell and have been shown to be involved in cancer cell growth, differentiation and the development of multi-drug resistance (MDR) mechanism. Therefore, GST inhibitors are emerging… read more here.
Keywords: degradation; cleavage; human gstp1; ligand induced ... See more keywords