Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49487-4
Abstract: The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin receptor-binding site have coevolved in… read more here.
Keywords: receptor; human h3n2; hemagglutinin; receptor binding ... See more keywords
Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041008
Abstract: The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor… read more here.
Keywords: influenza viruses; human h3n2; h3n2 influenza; influenza ... See more keywords