Calibration-free pTx of the human heart at 7T via 3D universal pulses.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.28952
Abstract: PURPOSE MRI at ultra-high fields in the human body is highly challenging and requires lengthy calibration times to compensate for spatially heterogeneous B 1 + profiles. This study investigates the feasibility of using pre-computed universal… read more here.
Keywords: human heart; ptx; calibration free; universal pulses ... See more keywords
Metabolite‐cycled echo‐planar spectroscopic imaging of the human heart
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29333
Abstract: Spectroscopic imaging could provide insights into regional cardiac triglyceride variations, but is hampered by relatively long scan times. It is proposed to synergistically combine echo‐planar spectroscopic imaging (EPSI) with motion‐adapted gating, weighted acquisition and metabolite… read more here.
Keywords: human heart; planar spectroscopic; spectroscopic; echo planar ... See more keywords
High‐resolution simulation of B0 field conditions in the human heart from segmented computed tomography images
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4739
Abstract: B0 inhomogeneity leads to imaging artifacts in cardiac magnetic resonance imaging (MRI), in particular dark band artifacts with steady‐state free precession pulse sequences. The limited spatial resolution of MR‐derived in vivo B0 maps and the… read more here.
Keywords: human heart; computed tomography; resolution; tomography images ... See more keywords
Modeling the human heart ex vivo—current possibilities and strive for future applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3335
Abstract: The high organ specification of the human heart is inversely proportional to its functional recovery after damage. The discovery of induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) has accelerated research in human heart regeneration and physiology.… read more here.
Keywords: human heart; vivo; ipsc cms; physiology ... See more keywords
Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2546-5
Abstract: Technical advances in generating and phenotyping cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to understand human heart disease and discover therapeutic targets that may lead… read more here.
Keywords: human heart; heart; human pluripotent; heart disease ... See more keywords
Precision medicine in human heart modeling
Sign Up to like & getrecommendations! Published in 2021 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-021-01421-z
Abstract: Precision medicine is a new frontier in healthcare that uses scientific methods to customize medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person. In cardiovascular health, precision medicine has emerged as… read more here.
Keywords: medicine; human heart; heart; precision medicine ... See more keywords
Deconvoluting the Cells of the Human Heart with iPSC Technology: Cell Types, Protocols, and Uses
Sign Up to like & getrecommendations! Published in 2022 at "Current Cardiology Reports"
DOI: 10.1007/s11886-022-01670-z
Abstract: Induced pluripotent stem cells (iPSCs) have become widely adopted tools in cardiovascular biology due to their ability to differentiate into patient-specific cell types. Here, we describe the current protocols, important discoveries, and experimental limitations from… read more here.
Keywords: human heart; cell; ipsc; deconvoluting cells ... See more keywords
On inotropic effects of UTP in the human heart
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e02197
Abstract: Uridine 5′-triphosphate (UTP) exerts a positive inotropic effect (PIE) in isolated electrically driven isolated right atrial trabeculae carneae from patients undergoing heart surgery. This review discusses some aspects of the current knowledge on the putative… read more here.
Keywords: human heart; heart; utp human; effects utp ... See more keywords
Toward the Goal of Human Heart Regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.12.004
Abstract: Heart regeneration, a relatively new field of biology, is one of the most active and controversial areas of biomedical research. The potential impact of successful human heart regeneration therapeutics cannot be overstated, given the magnitude… read more here.
Keywords: goal; human heart; heart; biology ... See more keywords
Distinct macrophage subsets in the human heart
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0053-5
Abstract: The human heart contains CC chemokine receptor type 2 (CCR2)+ and CCR2 macrophage subsets with distinct origins and functions, similar to the macrophage heterogeneity found in mouse hearts. Investigators used transmural left ventricular (LV) myocardial… read more here.
Keywords: human heart; heart; ccr2 macrophages; macrophage subsets ... See more keywords
Quantification of fuel use in the human heart
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-020-00476-2
Abstract: A metabolomics approach to assess heart energy metabolism in humans provides new insights into what fuels are used by both the failing and non-failing heart. read more here.
Keywords: use human; human heart; heart; quantification fuel ... See more keywords