Proteome-wide profiling and mapping of post translational modifications in human hearts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81986-y
Abstract: Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins. PTMs contribute to regulation of protein function and thereby greatly increase the functional diversity… read more here.
Keywords: human hearts; modifications human; post translational; proteome wide ... See more keywords
Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz043
Abstract: AIMS Heart failure patients commonly experience symptoms primarily during elevated heart rates, as a result of physical activities or stress. A main determinant of diastolic passive tension, the elastic sarcomeric protein titin, has been shown… read more here.
Keywords: human hearts; titin; heart; role ... See more keywords
Normalization strategy for selection of reference genes for RT-qPCR analysis in left ventricles of failing human hearts
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-022-02614-9
Abstract: Background Quantitative RT-PCR is a valuable tool for assessing the gene expression in different human tissues, particularly due to its exceptional sensitivity, accuracy and reliability. However, the choice of adequate control for normalization is a crucial… read more here.
Keywords: left ventricles; reference; human hearts; selection ... See more keywords
Determination of Agrin and Related Proteins Levels as a Function of Age in Human Hearts
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.813904
Abstract: Background: Mature cardiomyocytes are unable to proliferate, preventing the injured adult heart from repairing itself. Studies in rodents have suggested that the extracellular matrix protein agrin promotes cardiomyocyte proliferation in the developing heart and that… read more here.
Keywords: age human; determination agrin; age; heart ... See more keywords
Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041787
Abstract: Oxidative stress contributes to detrimental functional decline of the myocardium, leading to the impairment of the antioxidative defense, dysregulation of redox signaling, and protein damage. In order to precisely dissect the changes of the myocardial… read more here.
Keywords: human hearts; based redox; mass spectrometry; failing human ... See more keywords