Biodegradable Polymers as a Noncoding miRNA Nanocarrier for Multiple Targeting Therapy of Human Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801318
Abstract: Therapeutic strategy based on the restoration of tumor suppressor-microRNAs (miRNAs) is a promising approach for cancer therapy, but the low delivery efficiency of miRNA remains a huge hurdle due to the lack of safe and… read more here.
Keywords: hepatocellular carcinoma; peg bcpvs; mirna; mir26a mir122 ... See more keywords
Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30347
Abstract: Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between… read more here.
Keywords: expression; human hepatocellular; cd96; cell exhaustion ... See more keywords
Human hepatocellular carcinoma: Protection by melatonin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26586
Abstract: Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N‐acetyl‐5‐methoxytryptamine) is a multi‐tasking hormone that has long been… read more here.
Keywords: hepatocellular carcinoma; hcc; cancer; melatonin ... See more keywords
Synergy of Raddeanin A and cisplatin induced therapeutic effect enhancement in human hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.079
Abstract: Cisplatin is a main compound for human hepatocellular carcinoma (HCC) chemotherapies, but it has certain cytotoxicity during applications. To release that, combining with other drugs are being as a regular plan in clinic. In our… read more here.
Keywords: hepatocellular carcinoma; cisplatin; therapeutic effect; effect ... See more keywords
Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2017.05.004
Abstract: Background & Aims Cancer cells rely on metabolic alterations to enhance proliferation and survival. Metabolic gene alterations that repeatedly occur in liver cancer are largely unknown. We aimed to identify metabolic genes that are consistently… read more here.
Keywords: hepatocellular carcinoma; metabolic targets; metabolic genes; consistently altered ... See more keywords
Cell Penetrating Polymers Containing Guanidinium Trigger Apoptosis in Human Hepatocellular Carcinoma Cells unless Conjugated to a Targeting N-Acetyl-Galactosamine Block.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00598
Abstract: A series of 3-guanidinopropyl methacrylamide (GPMA)-based polymeric gene delivery vehicles were developed via aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymers have been evaluated for their cellular internalization ability, transfection efficiency, and cytotoxicity. Two… read more here.
Keywords: transfection efficiency; block; acetyl galactosamine; human hepatocellular ... See more keywords
Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45728
Abstract: Sesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been shown to have potential anticancer activities. This study aims at characterizing the antitumor efficacy of sesamol and unveiling the importance of mitochondria in… read more here.
Keywords: hepatocellular carcinoma; human hepatocellular; sesamol induced; sesamol induces ... See more keywords
Sphingolipidomic study of davidiin-treated HepG2 human hepatocellular carcinoma cells using UHPLC-MS
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DOI: 10.1039/c7ra11266a
Abstract: Davidiin, a natural product originating from Polygonum capitatum, has been proven to possess anti-hepatocellular carcinoma activity. To explore the mechanisms underlying the activity of davidiin, sphingolipids (SPLs) in HepG2 human hepatocellular carcinoma cells with or… read more here.
Keywords: hepatocellular carcinoma; hepg2 human; carcinoma cells; human hepatocellular ... See more keywords
Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line
Sign Up to like & getrecommendations! Published in 2020 at "Free Radical Research"
DOI: 10.1080/10715762.2020.1732955
Abstract: Abstract Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional… read more here.
Keywords: hepatocellular carcinoma; phosphorylated p62; huh cells; human hepatocellular ... See more keywords
MicroRNA-20a-5p regulates the epithelial-mesenchymal transition of human hepatocellular carcinoma by targeting RUNX3.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000001975
Abstract: BACKGROUND MicroRNA-20a (miR-20a) is dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC), but its expression level and functional significance in HCC are still disputed. We aimed to study the role of miR-20a-5p… read more here.
Keywords: expression; hepatocellular carcinoma; runx3; hcc ... See more keywords
MicroRNA‐301b‐3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14361
Abstract: Abstract MicroRNAs (miRNAs) are key regulators in the tumour growth and metastasis of human hepatocellular carcinoma (HCC). Increasing evidence suggests that miR‐301b‐3p functions as a driver in various types of human cancer. However, the expression… read more here.
Keywords: hcc; tumour growth; mir 301b; human hepatocellular ... See more keywords