Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2214-z
Abstract: Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose,… read more here.
Keywords: induced bosentan; hepatoma; omics based; human hepatoma ... See more keywords
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2018.09.007
Abstract: Berberine is an isoquinoline alkaloid extracted from Rhizoma coptidis and shows anti-hyperlipidemia effect in vivo and in vitro. We previously found that berberine could decrease the intracellular triglyceride content in human hepatoma HepG2 cells through… read more here.
Keywords: triglyceride lowering; human hepatoma; hepatoma hepg2; effect ... See more keywords
Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of environmental sciences"
DOI: 10.1016/j.jes.2016.05.028
Abstract: The antibacterial potential of silver nanoparticles (AgNPs) resulted in their increasing incorporation into consumer, industrial and biomedical products. Therefore, human and environmental exposure to AgNPs (either as an engineered product or a contaminant) supports the… read more here.
Keywords: silver nanoparticles; cell line; human hepatoma; hepatoma cell ... See more keywords
Lipidomic analysis of single and combined effects of polyethylene microplastics and polychlorinated biphenyls on human hepatoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126777
Abstract: Microplastics are an emerging environmental issue as a result of their ubiquity, persistence, and intrinsic toxic potential. In addition, their ability to sorb and transport a wide variety of environmental pollutants (i.e. "Trojan Horse" effect)… read more here.
Keywords: combined effects; lipidomic analysis; human hepatoma; single combined ... See more keywords
Formation Mechanism and Toxicological Significance of Biogenic Mercury Selenide Nanoparticles in Human Hepatoma HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00231
Abstract: It is widely recognized that the toxicity of mercury (Hg) is attenuated by the simultaneous administration of selenium (Se) compounds in various organisms. In this study, we revealed the mechanisms underlying the antagonistic effect of… read more here.
Keywords: hgse; human hepatoma; hgse nanoparticles; hepg2 cells ... See more keywords
Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b14559
Abstract: We base this study on the concept of drug repositioning to reconstitute the natural product of zingerone as zingerone nanoparticles (zingerone NPs) through a one-pot synthesized process. The as-fabricated zingerone NPs were characterized; they possessed… read more here.
Keywords: zingerone; human hepatoma; cell lines; zingerone nps ... See more keywords
Functional polarization of human hepatoma HepaRG cells in response to forskolin
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34421-8
Abstract: HepaRG is an original human hepatoma cell line, acquiring highly differentiated hepatic features when exposed to dimethylsulfoxide (DMSO). To search alternatives to DMSO, which may exert some toxicity, we have analyzed the effects of forskolin… read more here.
Keywords: human hepatoma; functional polarization; heparg cells; heparg ... See more keywords
Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174153
Abstract: Background Despite recent advances in treatment strategies, it is still difficult to cure patients with hepatocellular carcinoma (HCC). Sorafenib is the only approved multiple kinase inhibitor for systemic chemotherapy in patients with advanced HCC. The… read more here.
Keywords: jun; human hepatoma; cell lines; sorafenib ... See more keywords
Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG
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DOI: 10.3390/foods10010161
Abstract: 1,2-unsaturated pyrrolizidine alkaloids (PAs) belong to a group of secondary plant metabolites. Exposure to PA-contaminated feed and food may cause severe hepatotoxicity. A pathway possibly involved in PA toxicity is the disturbance of bile acid… read more here.
Keywords: acid homeostasis; human hepatoma; bile acid; pyrrolizidine alkaloids ... See more keywords
Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12020140
Abstract: Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells. Recently, we found that monoamine oxidase B (MAOB) catalyzed… read more here.
Keywords: hepatoma; maob; maob cells; endogenous gga ... See more keywords
MicroRNA-20 induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10435
Abstract: Methylation was suggested to suppress the transcriptional activity of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) in hepatocytes. This may be associated with its low replicative activity during the inactive stage of chronic… read more here.
Keywords: methylation; dna; hepatoma cells; human hepatoma ... See more keywords